There are several treatment modalities to date for central giant cell granuloma including conservative treatment and surgical treatment with often planned reconstruction of the bony defect. Spontaneous bone regeneration of mandibular defects following complete resection of mandible has rarely been reported in the literature. We report a case of spontaneous bone formation after resection of a ce...

Background: Periosteum-mediated bone regeneration (PMBR) is a known mandibular reconstruction. Though poorly understood and unpredictable, the concerns of developmental changes to donor recipient tissues shared by other treatment options appear nonexistent. The definitive role periosteum during in any mammal remains understood.
 Objective: To characterise genetic determinants PMBR mammals ...

Gingival overgrowth commonly seen in clinics can be categorized as generalized or localized. Peripheral giant cell granuloma (PGCG) is tumor like, non-neoplastic reactive intra-osseous lesion occurring the gingiva alveolar mucosa and characterized by an un-encapsulated proliferation of mononuclear polygonal cells which are spindle-shaped with osteoclast-type multinucleated a vascular background...

Congenital disease, major trauma, tumour resection and biphosphonate-related osteonecrosis can lead to partial, subtotal, or total loss of the mandibular bone. Minor defects can be easily reconstructed using bone grafts, whereas microvascular free tissue transfer may be unavoidable in the case of major bone loss or poor quality of soft tissue. Simple bone or composite osteocutaneous fibula free...

To address the functions of FGFR2 and FGFR3 signaling during mandibular skeletogenesis, we over-expressed in the developing chick mandible, replication-competent retroviruses carrying truncated FGFR2c or FGFR3c that function as dominant negative receptors (RCAS-dnFGFR2 and RCAS-dnFGFR3). Injection of RCAS-dnFGFR3 between HH15 and 20 led to reduced proliferation, increased apoptosis, and decreas...

OBJECTIVES To find diagnostic points and to identify the origin of osteomyelitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. METHODS Fifty-two patients with mandibular suppurative osteomyelitis and 25 patients with mandibular osteomyelitis in SAPHO syndrome were included in the study. Radiographic patterns of the lesion, types of periosteal reaction and the pre...