The precise biochemical nature of malignant transformation remains elusive. This article reviews some of the current theories of oncogenesis and aims to synthesize these concepts into a possible schema for the origins of malignant transformation, using a cell-programmed origin for neoplastic progression. It is proposed that cell transformation in malignancy is initiated by injury but finds ulti...

nial tumors and are histologically benign (1). A case of the transformation of an epidermoid cyst into a malignant squamous cell carcinoma has seldom been reported (2-7). The malignant transformation may have occurred from pre-existing epidermoid cysts or after the incomplete excision of an epidermoid cyst (5). The treatment of the malignant transformation of an epidermoid cyst varies from surg...

malignant lymphoma is the neoplastic transformation of cells, mostly originating from lymphoid tissues. malignant lymphoma has two major subtypes: hodgkin and non-hodgkin lymphoma. malignant lymphoma is the most common neoplasm in 3rd and 4th decades of life and more than two third of affected patients presented painless peripheral lymphadenopathy. involvement of waldeyer’s ring, epitrochlear a...

Malignant transformation of intracranial epidermoid cysts (IECs) is very rare. Clinical deterioration and contrast enhancement of a known IEC or at the surgical site of a removed IEC should raise suspicion for malignant transformation. There are very few reports and to our knowledge no reviews describing the spectral pattern of IEC undergone malignant transformation. We describe a rare case of ...

Background: Inflammatory myofibroblastic tumor (IMT) is a tumor composed of myofibroblasts and a mixed inflammatory infiltrate that rarely undergoes malignant transformation. The most common sites of involvement include the lung, liver and orbit, but it has been reported to occur in nearly every site of the body, including oral cavity and soft tissue. Although common in other sites, such a tumo...

BACKGROUND It is known that benign tumors have the potential for malignant transformation. Malignant transformation of vagus nerve schwannoma to angiosarcoma is very rare. METHODS We report a case of malignant transformation in which the initial diagnosis was subsequently altered to angiosarcoma originating from the vagus nerve. We compared the findings of MRI and fine-needle aspiration (FNA)...

We present a very rare case of malignant transformation of a benign mature cystic teratoma. The pathology report revealed malignant transformation of both the epithelial and sarcomatous elements of a benign dermoid cyst. To the best of our knowledge, this appears to be the third case of a malignant fibrous histiocytoma and a squamous cell carcinoma developing from a mature cystic teratoma. Mali...

background: inflammatory myofibroblastic tumor (imt) is a tumor composed of myofibroblasts and a mixed inflammatory infiltrate that rarely undergoes malignant transformation. the most common sites of involvement include the lung, liver and orbit, but it has been reported to occur in nearly every site of the body, including oral cavity and soft tissue. although common in other sites, such a tumo...

Malignant transformation of a mature cystic teratoma (MCT) is a very rare complication with an incidence of 0.17-2%;. The most common form of malignant transformation of the MCT is squamous cell carcinoma. Other tumors arising in MCT include basal cell carcinoma, sebaceous tumor, malignant melanoma, adenocarcinoma, sarcoma, and neuroectodermal tumor. However malignant transformation with metast...

Malignant transformation of a mature cystic teratoma (MCT) is an uncommon complication. The most common form of malignant transformation of a MCT is squamous cell carcinoma, representing 75% of malignant transformations. The frequency of malignant transformation of MCT to adenocarcinoma is just 6.8%. To the best of our knowledge, no case of para-aortic lymph node metastasis in mucinous adenocar...