Malignant hyperthermia is an extremely rare, potentially lethal disorder that occurs in susceptible patients who are exposed to triggering agents such as volatile anesthetic gases or depolarizing muscle relaxants. The clinical manifestations of malignant include hypermetabolism, hyperthermia, hypercapnia, and sustained skeletal rigidity, which result cardiac arrest, brain damage, death. It asso...

The objective – to summarize the current literature data on etiology, pathogenesis, diagnosis and treatment of malignant hyperthermia. search analysis hyperthermia in medical information systems PubMed, Сochrane librarу, Cyberleninka for last 10 years was performed with using keywords: «malignant hyperthermia», «dantrolene», «general anesthesia», «succinylcholine», «inhalation anesthetics». cri...

A 42-year-old man with neck squamous cell carcinoma underwent awake fiberoptic intubation and tumor resection under general anesthesia. He developed malignant hyperthermia several hours into the surgical procedure. This case highlights hyperthermia’s (MH) variable time course, pathognomonic signs, need for rapid diagnosis treatment. Early recognition treatment led to resolution of MH. Ongoing d...

Porcine malignant hyperthermia was studied in seven Pietrain pigs under standardized experimental conditions. In five animals malignant hyperthermia was triggered with suxamethonium and halothane, but in two pigs suxamethonium alone was used. Characteristic metabolic and physiological changes were found and these are discussed with regard to a possible mechanism to explain the malignant nature ...

Thirty pathologically diagnosed patients with grade III-IV primary or recurrent malignant glioma (tumor diameter 3-7 cm) were randomly divided into two groups. The control group underwent conventional radiotherapy and chemotherapy. In the hyperthermia group, primary cases received hyperthermia treatment, and patients with recurrent tumors were treated with hyperthermia in com-bination with radi...

1. Tautz TJ, Urwyler A, Antognini JF, Riou B: Case scenario: Increased end-tidal carbon dioxide. A diagnostic dilemma. ANESTHESIOLOGY 2010; 112:440 – 6 2. Kwetny IM, Finucane BT: Negative arterial to end-tidal carbon dioxide gradient: An additional sign of malignant hyperthermia during desflurane anesthesia. Anest Analg 2006; 102:815–7 3. Larach MG, Localio AR, Allen GC, Denborough MA, Ellis FR...

As more and more routine plastic surgery procedures move from the hospital to outpatient surgery facilities, plastic surgeons must be aware of the risk factors for life-threatening events that might occur in this setting. This awareness includes recognition of the signs and symptoms and the management of a rare but life-threatening condition, malignant hyperthermia. This article reviews the cur...