Poly(N-isopropylacrylamide) with two chain lengths (MW: ca. 5000, and ca. 20 000 g mol ) was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization, using 2-dodecylsulfanylthiocarbonylsulfanyl-2-methyl propionic acid as the chain transfer agent. The derivatization of terminal dodecyl groups to maleimide groups was performed through the reduction of terminal trithi...

A theoretical study on the multi-channel hydrogen addition of maleimide containing 2-hydroxy-benzophenone onto polyethylene in ultra-violet (UV) radiation cross-linking process was carried out using density functional theory (DFT) method at B3LYP/6–311 + G(d,p) level. The energetic information and minimum energy path (MEP) are calculated for nine reaction channels. electrophilic reactions two p...

Maleimide, N-ethyl-maleimide (NEM), and N-methyl-maleimide (NMM) were identified as potent catalytic inhibitors of purified human topoisomerase IIalpha, whereas the ring-saturated analog succinimide was completely inactive. Catalytic inhibition was not abrogated by topoisomerase II mutations that totally abolish the effect of bisdioxopiperazine compounds on catalytic inhibition, suggesting a di...

A novel biocompatible fast-gelling hydrogel has been explored for neurodegenerative diseases. The is formed using thiol-maleimide reaction. precursors maleimide modified 4-arm polyethylene glycol (PEG) and thiolated hyaluronic acid (HA) were created characterized by NMR.

Aminoacylation of RNA minihelices is speculated to be a key step in the transition from the putative RNA world to the theater of proteins. This reaction affords the opportunity to make chiral selection of an l- or d-amino acid and thus determine the ultimate chirality that is incorporated into proteins. Previous work showed chiral preference of aminoacylation with a nonprotein, nonribozyme, RNA...

Submodularity is an important  property of set functions with deep theoretical results  and various  applications. Submodular systems appear in many applicable area, for example machine learning, economics, computer vision, social science, game theory and combinatorial optimization.  Nowadays submodular functions optimization has been attracted by many researchers.  Pendant pairs of a symmetric...