Hyper-reactive malarial splenomegaly syndrome (HMSS) is a massive enlargement of the spleen due to an exaggerated immune response to repeated attacks of malaria. Tropical splenomegaly syndrome (TSS) is the most frequent cause of massive tropical splenomegaly in malarious areas [1-2]. It is seen more commonly among residents of endemic areas of malaria. It occurs mainly in tropical Africa, but a...

A distinctive type of hereditary ovalocytosis has been found in Papua New Guinea and a few areas of Southeast Asia. Its main features include a high incidence among tropical lowland dwellers, autosomal recessive inheritance, specific depression of a number of red cell antigens, a characteristic morphology in blood films, and an effect on the erythrocyte sedimentation rate. Speculation has occur...

background: plasmodium vivax malaria accounts for approximately 88% of malaria cases in iran. there is limited in­formation on genetic diversity of p. vivax in the country and a need to develop and apply an effective vaccine against the dis­ease is necessary. among many potential candidates, msp -3β gene is promising target. this study was designed and car­ried out to determine the variation of...

Development of resistance to DDT in malaria vectors is being reported from various parts of India. Jharkhand state in India is one of the high malaria endemic states with Plasmodium falciparum accounting for 44% of the cases1. In order to find out the rationale of using DDT in vector control, this study was carried out on insecticide susceptibility of malaria vectors in 12 endemic villages of s...

Background Malarious areas in Iran are close to Afghanistan and Pakistan that urge the researchers to extend their knowledge on malaria epidemiology to the neighboring countries as well. Vectorial capacity differs at species or even at population level, the first essential step is accurate identification of vectors. This study aimed to identify Anopheles species composition in selected malariou...

US military physicians and researchers helped identify the optimum treatment dose of the naturally occurring compound quinine and collaborated with the pharmaceutical industry in the development and eventual US Food and Drug Administration approval of the synthetic antimalarial drugs chloroquine, primaquine, chloroquine-primaquine, sulfadoxine-pyrimethamine, mefloquine, doxycycline, halofantrin...