Transcription of the Saccharomyces MAL structural genes is induced 40-fold by maltose and requires the MAL-activator and maltose permease. To identify additional players involved in regulating MAL gene expression, we carried out a genetic selection for MAL constitutive mutants. Strain CMY4000 containing MAL1 and integrated copies of MAL61promoter-HIS3 and MAL61promoter-lacZ reporter genes was u...

Résumé : Dans cet article nous explorons l’incomplétude des données dans le cadre de l’apprentissage de concepts propositionnels. Nous suivons l’idée de H. Hirsh qui étend le paradigme de l’espace des versions : dans cette extension une hypothèse doit être compatible (dans un sens à définir au cas par cas) avec toutes les informations relatives aux exemples. Nous proposons une représentation de...

The MAL proteolipid is a nonglycosylated integral membrane protein found in glycolipid-enriched membrane microdomains. In polarized epithelial Madin-Darby canine kidney cells, MAL is necessary for normal apical transport and accurate sorting of the influenza virus hemagglutinin. MAL is thus part of the integral machinery for glycolipid-enriched membrane-mediated apical transport. At steady stat...

Histone deacetylases (HDACs) are involved in the regulation of transcription and their inhibitors are a promising class of new anticancer drugs. We have previously reported Boc(Ac)Lys-AMC, also termed MAL, as a fluorescent substrate for HDACs. Now we present a modification of MAL called Z-MAL that is characterized by an increased rate of conversion by histone deacetylases of classes I and II an...

Clostridium perfringens ε-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with characteristics of blood-brain barrier (BBB) dysfunction and white matter injury. ETX has been proposed as a potential causative agent for Multiple Sclerosis (MS), a human disease that begins with BBB breakdown and injury to myelin forming cells of...

BACKGROUND Photodynamic therapy (PDT) has been shown to be an effective alternative for acne. However, there is little information comparing the efficacy of red light alone and methyl aminolaevulinate (MAL)-PDT. AIMS To compare the efficacy and tolerability of red light alone and MAL-PDT in patients with mild to moderate facial acne. METHODS Thirty six patients with mild to moderate acne we...

georges bernanos figure parmi les écrivains les plus importants du xxème siècle qui est récipiendaire du grand prix du roman de l'académie française pour son journal d'un curé de campagne en 1936. le journal relate l’histoire d’un curé de campagne qui ne réussit pas à établir le contact avec les paysans dont il a la charge. il est accusé d'avoir provoqué la mort de la comtesse qu...

georges bernanos figure parmi les écrivains les plus importants du xxème siècle qui est récipiendaire du grand prix du roman de l'académie française pour son journal d'un curé de campagne en 1936. le journal relate l’histoire d’un curé de campagne qui ne réussit pas à établir le contact avec les paysans dont il a la charge. il est accusé d'avoir provoqué la mort de la comtesse qui s'est enfermé...

The human mal gene, identified during a search for cDNAs selectively expressed during T-cell development, encodes a highly hydrophobic protein belonging to a group of proteins, termed proteolipids, characterized by their unusual property of being soluble in organic solvents used to extract cell lipids. To study the localization of the MAL protein we have prepared stable transfectants expressing...