background: the role of methadone in qtc prolongation, torsades de pointes (tdp) arrhythmia and sudden cardiac death has been debated. because of widespread use of methadone in methadone maintenance treatment (mmt) centers, we aimed to study dose-related effects of methadone on qtc prolongation. methods: in a comparative observational study, 90 patients who were under mmt were evaluated. patien...

Prophylactic maintenance therapy for one year using ranitidine 150 mg at night or a placebo was assessed in 68 patients whose gastric or duodenal ulcers had previously healed after therapy with ranitidine 150 mg twice daily or placebo. Gastroscopy was carried out on symptomatic relapse and at the end of the year. Of the duodenal ulcer group, seven out of 20 relapsed on ranitidine compared with ...

One hundred patients with benign gastric ulceration were treated in a single-blind, endoscopically controlled trial to assess the relative efficacy of cimetidine (1 g daily) and Caved-S (six tablets daily). Ulcer healing was assessed after six weeks' treatment, and, if incomplete, after a further six weeks. There was no significant difference between the two drug regimens (approximately 63% at ...

Background‎: The relationship between substance use and sleep is bidirectional. Substance use directly causes sleep disturbances, and sleep problems are a critical factor in substance-use relapse. Methods: This study evaluated sleep disorders in 65 methadone maintenance treatment (MMT) patients, and 61 opium-dependent patients who did not receive any treatment between September 2011 and July 20...

BACKGROUND The isolated recurrence of testicular leukemia in boys with acute lymphoblastic leukemia (ALL) is considered to be an ominous sign, heralding generalized recurrence. In general, treatment is comprised of systemic retreatment and local radiotherapy to one or both affected tests. METHODS In this study, the authors report five boys with a late isolated testicular recurrence of ALL dur...