Testosterone is a lipid-soluble molecule synthesized mainly from cholesterol in the testes, ovaries, and adrenal glands and is important for spermatogenesis and the development of both primary and secondary male sex characteristics. Anabolic steroids, which have similar properties to testosterone, are commonly taken by athletes and body builders to increase performance, however, they possess da...

The high incidence of low sperm counts in young (European) men and evidence for declining sperm counts in recent decades mean that the environmental/lifestyle impact on spermatogenesis is an important health issue. This review assesses potential causes involving adverse effects on testis development in perinatal life (primarily effects on Sertoli cell number), which are probably irreversible, o...

With an increasing incidence of male idiopathic infertility, identification of novel genes involved in spermatogenesis is an important aspect for the understanding of human testicular failure. In the present study, we have identified a novel gene Spata33, also called as 4732415M23Rik or C16orf55, which is conserved in mammalian species. Spata33 was predominantly expressed in the postpartum and ...

Spermatogenesis is a highly coordinated physiological process that requires the correct expression and functions of thousands of developmentally regulated genes. The regulation of spermatogenesis is not well defined, since majority of the related genes have neither been identified nor fully characterized. Hence, it is meaningful to identify and characterize these genes to reveal the mechanism u...

Germinal epithelium of seminiferous tubules in adult, infertile hypodactylous males displays significant reduction in the number of germ-line cells. Detection of apoptosis in the germ-line cells during postnatal differentiation was performed to elucidate the mechanism of the decreased number of germ cells in the testes of adult rats. Evaluation of DNA fragmentation and expression of activated c...

Introduction. Experimental induction of spermatogenesis disorders is possible mainly by physical, pharmacological methods. However, not all methods can cause non-obstructive azoospermia. Objective. To evaluate and compare the effectiveness in rat models applying ligatures to spermatic cords administration cisplatin. Materials & . Seventy-three mature male rats (Wistar) were divided into 2 e...

Multiple genes are restrictively expressed in mammalian testicular tissues, and they play important roles in the complex process of spermatogenesis. Investigation of these genes and their expression regulation mechanisms is valuable to elucidate the molecular process of spermatogenesis. In this study, we identified a novel human gene, ring finger protein 148 (RNF148) that is abundantly expresse...

Spermatogenesis, a highly conserved process in vertebrates, is mainly under the hypothalamic-pituitary control, being regulated by the secretion of pituitary gonadotropins, follicle stimulating hormone, and luteinizing hormone, in response to stimulation exerted by gonadotropin releasing hormone from hypothalamic neurons. At testicular level, gonadotropins bind specific receptors located on the...

spermatogenesis process during which the male germ cells are produced at each stage of the disorder, it can lead to infertility. the aim of this study was to evaluate the effect of fennel and yarrow on spermatogenesis in adult micereceiving chemotherapy is cyclosporine. for this study, 32 male wistar rats with an average weight of 20 ± 200 g were randomly divided into four groups (control, cycl...