More than 20 years ago, it was hypothesized that intracellular hyperthermia is superior to extracellular hyperthermia. It was further hypothesized that even a single biological cell containing magnetic nanoparticles can be treated for hyperthermia by an AC magnetic field, independent of its surrounding cells. Since experimental investigation of the thermal effects of intracellular hyperthermia ...

We present a proof of concept on the use of thermomagnetic polymer films (TMFs) as heating devices for magnetic hyperthermia in vitro. The TMFs were prepared through spray assisted layer-bylayer assembly of polysaccharides and magnetic iron oxide nanoparticles, yielding an alternate magnetic-polymer multilayer structure. By applying a remote alternating magnetic field (AMF) (f = 180 kHz; H = 35...

BACKGROUND Induction heating devices using the induction coil and magnetic nanoparticles (MNPs) are the way that the magnetic hyperthermia is heading. OBJECTIVE To facilitate the induction heating of in vivo magnetic nanoparticles in hyperthermia experiments on large animals. METHODS An induction heating device using a planar coil was designed with a magnetic field frequency of 328 kHz. The...

Introduction: Recently, some studies have focused on dendrimer nanopolymers as an MRI contrast agent or a vehicle for gene and drug delivery. Considering the suitable properties of these materials, they are appropriate candidates for coating iron oxide nanoparticles which are applied to magnetic hyperthermia. To the best of our knowledge, the novelty of this study is the inves...

Magnetic-nanoparticle-mediated intracellular hyperthermia has the potential to achieve localized tumor heating without any side effects. The technique consists of targeting magnetic nanoparticles to tumor tissue followed by application of an external alternating magnetic field that induces heat through Néel relaxation loss of the magnetic nanoparticles. The temperature in tumor tissue is increa...

Localized magnetic hyperthermia using magnetic nanoparticles (MNPs) under the application of small magnetic fields is a promising tool for treating small or deep-seated tumors. For this method to be applicable, the amount of MNPs used should be minimized. Hence, it is essential to enhance the power dissipation or heating efficiency of MNPs. Several factors influence the heating efficiency of MN...

Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing ...

Colloidal nanocrystal assemblies (nanoclusters), consisting of 13 nm iron oxide nanocrystals, were synthesized in various sizes (45-98 nm), and were investigated as heating mediators for magnetic particle hyperthermia. The colloidal nanocrystal clusters show enhanced heating efficiency in comparison with their constituent primary iron oxide nanocrystals due to collective magnetic features. The ...

This work examines feasibility, practical advantages, and disadvantages of a combined MRI/magnetic particle hyperthermia (MPH) system for cancerous tumor treatment in low perfusion tissue. Although combined MRI/hyperthermia systems have been proposed and constructed, the current proposal differs because the hyperthermia system would be specifically designed to interact with the magnetic nanopar...

Bone Tumor Suppression Magnetic bone cement incorporating magnetically soft zinc ferrite nanoparticles and aligned in a direct current magnetic field realized exceptionally high heating power live animals under clinically safe parameters for hyperthermia. of osteosarcoma rabbits by hyperthermia substantially enhances survival rate. More details can be found article number 2104626 Shuli He, Qing...