Here, we report a natural chemical Matrine, which exhibits anti-melanoma potential with its PTEN activation mechanism. Matrine effectively inhibited proliferation of several carcinoma cell lines, including melanoma V600EBRAF harboring M21 cells. Flow cytometry analysis showed Matrine induced G0/G1 cell cycle arrest in M21 cells dose-dependently. Apoptosis in M21 cells induced by Matrine was ide...

We consider the nonsymmetric algebraic Riccati equation XM12X + XM11 + M22X + M21 = 0, where M11,M12,M21,M22 are real matrices of sizes n × n, n × m,m × n, m × m, respectively, and M = [Mij ]i,j=1 is an irreducible singular M matrix with zero row sums. The equation plays an important role in the study of stochastic fluid models, where the matrix −M is the generator of a Markov chain. The soluti...

S100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis by stimulating angiogenesis. We demonstrated that S100A4 synergizes with vascular endothelial growth factor (VEGF), via the RAGE receptor, in promoting endothelial cell migration by increasing KDR expression and MMP-9 activity. In vivo overexpression of S100A4 led to a signifi...

A monoclonal antibody, 9.2.27, with a high specificity for human melanoma cell surfaces has been utilized for biosynthetic studies in M21 human melanoma cells to define a unique antigenic complex consisting of a 250-kilodalton N-linked glycoprotein and a high molecular weight proteoglycan component larger than 400 kilodaltons. The 250-kilodalton glycoprotein has endoglycosidase H-sensitive prec...

We study how well KamLAND, the first terrestrial neutrino experiment capable of addressing the solar neutrino problem, will perform in ascertaining whether or not the large mixing angle MSW solution (with 10 < ∆m21 < 10 −3 eV and oscillation amplitude sin2 θ12 > 0.2) is correct. We find that in a year of operation KamLAND will provide unequivocal evidence for or against this solution. Furthermo...

We measured denitrification and total nitrate uptake rates in a small stream (East Fork of Walker Branch in eastern Tennessee) using a new field 15N tracer addition and modeling approach that quantifies these rates for entire stream reaches. The field experiment consisted of an 8-h addition of 99 atom% KNO3 and a conservative solute tracer. Two 15N tracer addition experiments were performed on ...

17 Longitudinally Extensive Spinal Neurosarcoid from the Brainstem to T3 T4 Jacob E. Voelkel, M.D.1, Joseph Loeb, D.O.2, Salvador Rios, M21, Amgad Masoud, M.D.3 1University of Missouri-Kansas City School of Medicine, Kansas City, MO 2University of Missouri-Kansas City School of Medicine, Department of Radiology 3University of Missouri-Kansas City School of Medicine, Department of Internal Medicine