نتایج جستجو برای: m14
تعداد نتایج: 450 فیلتر نتایج به سال:
In support of the recent article by Chambers (1), we wish to share our data on the origin of the MDA-MB-435 and M14 cell lines. Chambers claims that it is most plausible that both cell lines represent MDA-MB-435 based on two X chromosomes in the MDAMB-435 karyotype, whereas M14 had been derived from a man (1). However, karyotyping does not discriminate between paternal and maternal alleles and ...
Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells
Primary or acquired resistance to MEK inhibitors has been a barrier to successful treatment with MEK inhibitors in many tumors. In this study, we analyzed genome-wide gene expression profiling data from 6 sensitive and 6 resistant cell lines to identify candidate genes whose expression changes are associated with responses to a MEK inhibitor, selumetinib (AZD6244). Of 62 identified differential...
It has been confirmed that multidrug resistant (MDR) melanoma cells (M14 ADR2) are more sensitive than their wild-type counterparts (M14 WT) to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine. The metabolites formed by BSAO and spermine are more toxic, in M14 cells, than exogenous H2O2 and acrolein, even though their concentration is lower d...
Establishment of a tet-on gene expression system in glucose-responsive and -unresponsive MIN6 cells.
The tetracycline (or doxycycline)-inducible gene expression (Tet-On) system developed by Gossen and Bujard (1) is useful for controlling the expression of targeted genes and for determining the roles of the gene products in cellular functions. The Tet-On system has recently been applied to the rat insulinoma cell line INS-1 to study the roles of wild-type and mutant genes in insulin secretion (...
The high temperature form of melanophlogite, 46 Si02. 6M14 .2M12(M12=CH4, N2; M14=C02, N2), is cubic with space group Pm3n and a = 13.436(3) A at 200°C. The mineral is isostructural with the cubic gas hydrates of type I. Structure refinement with 667 independent reflections led to a weighted Rw = 0.040. Corner-sharing [Si04] tetrahedra form a 3dimensional framework which contains two types of c...
Sugar beet is a species of the Chenopodiaceae family. It is an important sugar crop that supplies approximately 35% of the sugar in the world. Sugar beet M14 line is a unique germplasm that contains genetic materials from Beta vulgaris L. and Beta corolliflora Zoss. And exhibits tolerance to salt stress. In this review, we have summarized OMICS technologies and applications in sugar beet includ...
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