نتایج جستجو برای: m13 phage

تعداد نتایج: 20629  

ژورنال: پژوهش در پزشکی 2013
رجبی بذل, معصومه, رفیعی ده بیدی, غلامرضا, موسوی, سید لطیف, یغمایی, بهرام,

Abstract Background: Removal of prostate and radiotherapy are used routinely for treatment of prostate cancer however in advanced stages of the disease these treatments are ineffective. Researchers are exploring strategies for preventing this malignancy. This study aims to design and develop a phage based vaccine for preventing prostate cancer. Materials and methods: After conducting bioinforma...

2013
Murali Murugesan Gopal Abbineni Susan L. Nimmo Binrui Cao Chuanbin Mao

Owing to the genetic flexibility and error-free bulk production, bio-nanostructures such as filamentous phage showed great potential in materials synthesis, however, their photo-responsive behaviour is neither explored nor unveiled. Here we show M13 phage genetically engineered with tyrosine residues precisely fused to the major coat protein is converted into a photo-responsive organic nanowire...

2012
Keisuke Fukunaga Masumi Taki

Phage display technology is undoubtedly a powerful tool for affinity selection of target-specific peptide. Commercially available premade phage libraries allow us to take screening in the easiest way. On the other hand, construction of a custom phage library seems to be inaccessible, because several practical tips are absent in instructions. This paper focuses on what should be born in mind for...

Journal: :iranian journal of public health 0
n aghabeigi n lindsey a zamani b shishaeyan

background: the autoimmune disease known as idiopathic (immune thrombocytopenic purpura thrombocytopenic purpura (itp) is clinically defined by a low numbers of platelets in the circulation blood. this study aimed to isolate autoantibodies made against the platelet glycoproteins using platelets from healthy volunteers, to determine their specificity and further elucidate their effects on platel...

Objective(s): Filamentous bacteriophage M13 was genetically engineered to specifically target mammalian cells for gene delivery purpose. Materials and Methods: A vascular endothelial growth factor receptor 2 (VEGFR2)-specific nanobody was genetically fused to the capsid gene III of M13 bacteriophage (pHEN4/3VGR19). A mammalian expression construct containing Cop-green fluorescent protein (Cop-G...

Journal: :Nano letters 2012
Hyunjung Yi Debadyuti Ghosh Moon-Ho Ham Jifa Qi Paul W Barone Michael S Strano Angela M Belcher

Second near-infrared (NIR) window light (950-1400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13 phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of tumors. M13-SWNT probe is detectable in dee...

Journal: :ACS synthetic biology 2013
Gaelen T Hess Carla P Guimaraes Eric Spooner Hidde L Ploegh Angela M Belcher

M13 bacteriophage has been used as a scaffold to organize materials for various applications. Building more complex multiphage devices requires precise control of interactions between the M13 capsid proteins. Toward this end, we engineered a loop structure onto the pIII capsid protein of M13 bacteriophage to enable sortase-mediated labeling reactions for C-terminal display. Combining this with ...

Journal: :Journal of molecular biology 2011
Rosemarie Vithayathil Richard M Hooy Melanie J Cocco Gregory A Weiss

Numerous examples of phage display applied to soluble proteins demonstrate the power of the technique for protein engineering, affinity reagent discovery and structure-function studies. Recent reports have expanded phage display to include membrane proteins (MPs). The scope and limitations of MP display remain undefined. Therefore, we report data from the phage display of representative types o...

Journal: :Journal of Biomaterials and Nanobiotechnology 2016

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