Lysophosphatidic acid (LPA) known as a serum-derived growth factor, is involved in several cell physiological functions in the female reproductive system including: oocyte maturation, in vitro fertilization and embryo implantation by its transmembrane G protein-coupled receptors. The aim of the present study was to examine the effect of LPA on in vitro follicular development o...

Activation of platelets induces the formation of phosphatidic acid, which results from the combined actions of a phosphatidylinositol-specific phospholipase C and a 1,2-diacylglycerol kinase. It has been proposed that this phosphatidic acid leads in some way to the subsequent production of arachidonic acid. The present studies reveal the existence of a particulate phospholipase Az enzyme that a...

Lysophosphatidic acid (1-acyl-sn-glycero-3-phosphate (LPA)) is a phospholipid with diverse biological activities. The mediator serves as an intermediate in membrane phospholipid metabolism but is also produced in acute settings by activated platelets. LPA is converted to phosphatidic acid, itself a lipid mediator, by an LPA acyltransferase (LPAAT). A human expressed sequence tag was identified ...