We found a high rate (4.2%) of positive results for lysergic acid diethylamide (LSD) by Emit in 1898 urine samples that were submitted primarily from psychiatric patients for drugs-of-abuse (DOA) testing. Specimens that tested positive for LSD by Emit subsequently tested negative for LSD with two RIAs. Furthermore, LSD was not detected in randomly selected Emit-positive urine samples by gas chr...

The past decade brought the beginnings of a renaissance in research on psychedelic drugs. Two articles in this issue of Biological Psychiatry signify that the resurrection of this longignored topic has begun to mature and bear at least the promise of fruit. In the early 1970s, the onset of the “War on Drugs” brought with it a near-total hiatus in serious research on psychedelic drugs, especiall...

Screening large numbers of urine samples for drugs of abuse is typically accomplished using immunoassays that allow for processing large numbers of samples without the requirement of sample preparation before analysis. Until fairly recently, screening of lysergic acid diethylamide (LSD) in urine samples could only be accomplished by the use of radioimmunoassays (RIA). Recently, new nonisotopic ...

This article presents a historical overview along with the general characteristics of lysergic acid diethylamide (LSD). The increasingly popular new derivatives LSD were also included. Their changing legal status over time was presented, followed by an attempt to interpret mass spectrum analysing fragmentation pathways molecule using 1P-LSD as example. Attention paid method sample preparation, ...

The unavailability of a suitable preanaesthetic medicament is discussed. A double blind comparison of placebo, meprobamate and pentobarbital as preanaesthetic medicants for regional procedures is presented. The authors have determined the effects of each of these treatments on patient's apprehension, cooperation, drowsiness, reaction to painful stimuli, talkativeness, nausea and emesis. The ana...