نتایج جستجو برای: lymphopenia

تعداد نتایج: 2617  

2014
Bruno Moltedo Saskia Hemmers Alexander Y. Rudensky

Regulatory T (Treg) cells enforce T cell homeostasis and maintain peripheral T cell tolerance. Here we report a previously unappreciated phenomenon of acute T cell lymphopenia in secondary lymphoid organs and non-lymphoid tissues triggered by Treg cell depletion that precedes the expansion of self-reactive T cells. Lymphopenia affects both neonates and adults indicating a dominant role of Treg ...

Journal: :Journal of immunology 2004
Thomas Schüler Günter J Hämmerling Bernd Arnold

Healthy, nonimmunized C57BL/6 (B6) mice contain memory phenotype CD8+ T cells, which are assumed to be generated in response to environmental Ags. Since neonatal mice are functionally lymphopenic within the first days after birth, we investigated the alternative possibility that the memory CD8+ T cells of untreated B6 mice are the result of lymphopenia-induced proliferation during neonatal life...

Journal: :Leukemia & lymphoma 2010
Jorge J Castillo Domingo Morales Pilar Quinones Esther Cotrina Carlos Desposorio Brady Beltran

Peripheral T-cell lymphoma, unspecified (PTCLU) is the most common T-cell lymphoma variant. The molecular heterogeneity of PTCLU is reflected by a diverse clinical course. Several prognostic factors have been studied, but further refinement is needed. The aim of our study was to retrospectively evaluate the presence of lymphopenia, defined as a lymphocyte count of<1000 cells/mm³, as a prognosti...

Journal: :Blood 2009
Armelle Le Campion Marie-Claude Gagnerault Cédric Auffray Chantal Bécourt Maud Poitrasson-Rivière Eliette Lallemand Boris Bienvenu Bruno Martin Françoise Lepault Bruno Lucas

Lymphopenia is thought to be a major cause of tolerance breakdown. In a lymphopenic environment, self-recognition events induce some T cells to expand strongly (a mechanism known as spontaneous proliferation). In this study, we show that in C57BL/6 mice, the repertoire resulting from lymphopenia-induced spontaneous CD4(+) T-cell proliferation included a proportion of regulatory T cells as large...

Journal: :Archive of internal medicine 2016

Journal: :PLoS ONE 2009
Sabine Stegemann Sofia Dahlberg Andrea Kröger Marcus Gereke Dunja Bruder Birgitta Henriques-Normark Matthias Gunzer

Influenza A virus (IAV) causes respiratory tract infections leading to recurring epidemics with high rates of morbidity and mortality. In the past century IAV induced several world-wide pandemics, the most aggressive occurring in 1918 with a death toll of 20-50 million cases. However, infection with IAV alone is rarely fatal. Instead, death associated with IAV is usually mediated by superinfect...

Journal: :Archives of Disease in Childhood 2000

Journal: :The American journal of tropical medicine and hygiene 1998
M W Richards R H Behrens J F Doherty

We conducted a retrospective analysis of hematologic changes in 89 patients with imported Plasmodium falciparum malaria. Thirteen (15%) were anemic at presentation, 60 (67%) had thrombocytopenia, and 63% had lymphopenia. There was a significant inverse relationship between parasitemia and platelet count. Anemia is rare among patients with imported malaria, while thrombocytopenia and lymphopenia...

2017
Felix Bongomin Chris Harris Philip Foden Chris Kosmidis David W Denning

We evaluated the expression of biomarkers of innate and adaptive immune response in correlation with underlying conditions in 144 patients with chronic pulmonary aspergillosis (CPA). Patients with complete medical and radiological records, white cell counts, and a complete panel of CD3, CD4, CD8, CD19, and CD56 lymphocyte subsets were included. Eighty-four (58%) patients had lymphopenia. Six (4...

2011
Yu Ri Kim Jin Seok Kim Soo Jeong Kim Hyun Ae Jung Seok Jin Kim Won Seog Kim Hye Won Lee Hyeon Seok Eom Seong Hyun Jeong Joon Seong Park June-Won Cheong Yoo Hong Min

BACKGROUND Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of aggressive T-cell lymphomas with poor treatment outcomes. The aim of this study was to evaluate whether lymphopenia at diagnosis would have an adverse effect on survival in patients with PTCL-NOS treated with anthracycline-containing chemotherapy. METHODS A total of 118 patients with PTCL-NOS...

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