نتایج جستجو برای: lymphocyte antiproliferative factor

تعداد نتایج: 904013  

Journal: :Molecular endocrinology 2005
Lars-Göran Bladh Johan Lidén Ahmad Pazirandeh Ingalill Rafter Karin Dahlman-Wright Stefan Nilsson Sam Okret

Glucocorticoid hormones (GCs) exert an antiproliferative effect on most cells. However, the molecular mechanism is still largely unclear. We investigated the antiproliferative mechanism by GCs in human embryonic kidney 293 cells with stably introduced glucocorticoid receptor (GR) mutants that discriminate between cross-talk with nuclear factor-(kappa)B (NF-(kappa)B) and activator protein-1 sign...

Journal: :The Journal of pharmacology and experimental therapeutics 1998
O Kosonen H Kankaanranta M Lähde P Vuorinen P Ylitalo E Moilanen

Two novel nitric oxide (NO)-releasing oxatriazole derivatives, GEA 3162 and GEA 3175, and an earlier known NO donor, S-nitroso-N-acetylpenicillamine (SNAP), inhibited cell proliferation and enhanced cGMP production in a concentration-dependent manner in human lymphocytes activated by lectin mitogen concanavalin A (ConA). The possible mediator role of cGMP in the antiproliferative action of NO d...

حاجی حسینلو, وحدت , شیربازو, شهناز , صحرایی, صحرایی,

Background: Protozoa are unicellular eukaryotes. A type of intestinal protozoan pathogens is the cause of infection and serious injuries in human with or without clinical symptoms. It seems that parasitic infections as a stressor factor can affect on stress system activity and immune system function and sensitivity. The major purpose of this paper was to evaluate serum cortisol level and the ge...

Journal: :Bioscience, biotechnology, and biochemistry 2007
Motoko Oarada Tohru Gonoi Tsuyoshi Tsuzuki Miki Igarashi Katsuya Hirasaka Takeshi Nikawa Yuko Onishi Takahito Toyotome Katsuhiko Kamei Teruo Miyazawa Kiyotaka Nakagawa Minoru Kashima Nobuyuki Kurita

Psychological stress has been shown to modulate immune functions. In this study, we investigated the effect of dietary oils (olive oil, soybean oil, and fish oil) on the social isolation stress-induced modulation of lymphocyte immunological activities in mice. In olive oil-fed, but not soybean oil- or fish oil-fed, mice, a 2-week isolation stress decreased the lymphocyte proliferative response,...

Journal: :Mediators of Inflammation 1998
A L Pukhalsky S D Shyian E A Kalashnikova G V Shmarina D A Pukhalskaya N V Bovin

Immunomodulating effects of a neoglycoconjugate created on the basis of alpha1-acid glycoprotein (AGP) carbohydrate chains and synthetic protein-free carrier have been investigated. It was demonstrated that this pseudo-AGP suppressed PHA- or anti-CD3 antibody-induced lymphocyte proliferation in a dose-dependent manner. Pseudo-AGP revealed a similar antiproliferative effect as the natural AGP sa...

Journal: :Infection and immunity 1980
M C Rattray G M Peterman L C Altman L Corey K K Holmes

Lymphocyte transformation and production of lymphocyte-derived chemotactic factor in response to herpes simplex virus antigen were studied in 15 patients with initial genital herpes and 10 controls. The patients underwent frequent genital examinations, viral cultures, and weekly immunological studies for a period of 11 weeks. The production of lymphocyte-derived chemotactic factor was maximal i...

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