In cancer, the lymphatic system is hijacked by tumor cells that escape from primary and metastasize to sentinel lymph nodes. Tumor lymphangiogenesis stimulated vascular endothelial growth factors-C (VEGFC) after binding its receptor VEGFR-3. However, how VEGFC cooperates with other molecules promote lymphatics has not been fully determined. We showed developed in tumoral lesions surrounding adi...

abstract background and aim: survivin is a new member of inhibitor of apoptosis protein family (iap) that plays an important role in the regulation of cell cycle and inhibition of apoptosis. distinct expression of this gene in tumoral cells versus normal cells introduces it as the fourth major transcriptome in cancers. thyroid carcinoma is the most common endocrine malignancy. considering the h...

BACKGROUND Colorectal cancers (CRCs) with microsatellite instability (MSI) are associated with a good prognosis and a high density of tumor-infiltrating lymphocytes (TILs). We have undertaken to determine the link between TIL densities and MSI CRC histologic features. PATIENTS AND METHODS Using tissue microarrays, T-cell sub-population infiltration, including T cells (CD3), cytotoxic T cells ...

background and aims. mast cells are one of the characteristic factors in angiogenesis, growth, and metastatic spread of tumors. the distribution and significance of mast cells in many tumors have been demonstrated. however, few studies have evaluated mast cell infiltration in salivary gland tumors. in this study, mast cell counts were evaluated in benign and malignant salivary gland tumors. mat...

background: differentiation, migratory properties and availability of mesenchymal stromal cells (msc) have become an important part of biomedical research. however, the functional heterogeneity of cells derived from different tissues has hampered providing definitive phenotypic markers for these cells. objective: to characterize and compare the phenotype and cytokines of adipose derived mscs (a...

AIM The aim of this work was to assess caspase-3 activity in the tissue of papillary thyroid carcinomas of patients and analyze the peculiarities of changes in this activity depending upon a number of pathomorphological and clinical features of tumoral process. METHODS Caspase-3 activity was determined by spectrophotometry with regard to acetyl-asp-glu-val-asp-paranitroanilide. RESULTS At i...

that metastasis often occurs early in tumor progression. In early stage breast cancer, for example, a significant percentage of patients exhibit circulating tumor cells (CTC's) and disseminated bone marrow tumor cells (DTC's) [1,2]. More direct experimental evidence for " early metastasis " has been observed in studies of transgenic mice expressing a cancer-causing oncogene where the primary ca...

OBJECTIVE In recent studies focusing on the prognostic significance of histologic features of NSCLC tumors, vessel invasion was correlated to survival across all surgical stages. We similarly analyzed whether intra-tumoral permeation could affect survival in subgroups of stage I and II NSCLC. METHODS A retrospective single institution analysis of a prospectively computed database. Specimens w...

background: colorectal adenocarcinoma is one of the most prevalent and treatable malignancies of the gastrointestinal tract. pattern of expression of the p53, p21, p16, e-cadherin and |î²|-catenin proteins are shown to be related to the prognosis of this malignancy. we aimed to compare the pattern of expression of these proteins in tumoral and nontumoral mucosal cells of cancer and on-cancer pa...