نتایج جستجو برای: lymphatic metastases
تعداد نتایج: 72157 فیلتر نتایج به سال:
To validate the correlation between ANXA3 expression and prognosis in breast cancer, a retrospective study encompassing 309 breast cancer patients was performed. The expression of ANXA3 was determined by the immunohistochemical examination of tissue sections by the Max Vision™ method. The ANXA3 levels in the patient samples were validated for the prognosis based on age, menopause status, tumor ...
BACKGROUND Carcinoma of the thyroid gland is one of the most commonly encountered endocrine malignancies. Papillary carcinoma is the most common histological type, and its spread is usually lymphatic. About 30-80% patients with papillary carcinoma develop lymphatic metastases. CASE REPORT We present here the case of a 70-year-old female patient who had undergone total thyroidectomy 10 years p...
AIM To investigate the distribution pattern of lymphatic vessels and microvessels in sporadic colorectal carcinoma (SCRC) and their relationship to metastasis and prognosis. METHODS The lymphatic vessel density (LVD) and microvessel density (MVD) in tumor tissue obtained from 132 patients with primary SCRC, including 74 with metastases and 58 without metastases, were evaluated by immunohistoc...
Metastasis, the spread of tumor cells from the primary site to lymph nodes and the distant organs is the most aggressive and specific feature of malignant cancer. The mechanisms by which malignant cells leave the primary tumor, invade lymphatics and metastasize are complex and interconnected being directly related to biological behavior of tumor. However, the lymphatic vasculature is often negl...
BACKGROUND In spite of radical gastrectomy with resection of the lymphatic system, where no metastases are found during histopathological examination, about 30% of patients have relapse of the neoplastic process. This situation may be caused by micrometastases or isolated neoplastic cells in the lymphatic system which were not identified during a standard histopathological examination. AIM Th...
BACKGROUND Results of a dynamic multimodality mapping study showed no lymphatic drainage of the lateral bladder wall to the contralateral internal iliac region. OBJECTIVES To validate whether pathoanatomical mapping in bladder cancer (BC) patients can confirm these results. METHODS Between 01/2000 and 07/2013, 825 BC patients preoperatively staged ≥pT1 and without clinical signs of metastas...
Lymphatic vessels play a crucial role in both the pathophysiology of tumors and in the spread cancer cells to lymph nodes. The effects of radiation on these vessels, however, are largely unknown. Here, we seek to describe the effects of ionizing radiation on normal and tumor-associated lymphatic vessels in vitro and in vivo. Clonogenic assays were employed to study the radiation dose response o...
Although approximately 50% of cancers give rise to metastases via the lymphatic system, the mechanisms mediating this process have remained unknown. In this study, we have investigated the role of two lymphatic endothelial molecules, the mannose receptor (MR) and common lymphatic endothelial and vascular endothelial receptor (CLEVER)-1 in adhesion of malignant cells to the lymphatic endothelium...
BACKGROUND Pathological examination after endoscopic submucosal dissection revealed that a 62-year-old male had esophageal squamous cell carcinoma with lamina propria mucosal invasion and lymphatic permeation. CASE PRESENTATION The patient underwent subtotal esophagectomy and reconstruction as an additional therapy. At 3 years and 4 months after esophagectomy, enlargement of abdominal para-ao...
Lymph nodes are the first site of metastases for most types of cancer, and lymph node status is a key indicator of patient prognosis. Induction of tumor lymphangiogenesis by vascular endothelial growth factor-C (VEGF-C) has been shown to play an important role in promoting tumor metastases to lymph nodes. Here, we employed receptor-specific antagonist antibodies in an orthotopic spontaneous bre...
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