Abstract Helminth parasites induce potent host type 2 immune responses (T2I) that promote parasite clearance and prevent reinfection. The parasite-induced T2I involve both innate adaptive cell components, but how the activation of different types is coordinated during initiation incompletely understood. Dendritic cells (DCs) are best known for their role in bridging immunity by sensing immunolo...

Introduction: The World Health Organization in March 2020 announced a pandemic of COVID-19 disease caused by the SARS-CoV-2 virus. It is one seven species known to be pathogenic humans this group viruses. incubation period virus 2-14 days, usually about 5 days. uses ACE2 receptor enter host's mucosa and cause an active infection. Symptomatic infection may complicated reversible or irreversible ...

This article relates the current pathophysiologic and radiologic findings to fundamental idea of acute lung epithelial infection, alveolar inflammation causing leak into interstitial space, subsequent secondary or concurrent endothelial infection dysfunction. Understanding mechanisms timings damage can better inform types ventilatory support required timing targeted pharmacotherapies.

Community associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging threat to human health throughout the world. Rodent MRSA pneumonia models mainly focus on the early innate immune responses to MRSA lung infection. However, the molecular pattern and mechanisms of recovery from MRSA lung infection are largely unknown. In this study, a sublethal mouse MRSA pneumonia model w...

cryptosporial and bacterial co-infection is reported in a budgerigar with clinical manifestations of septicemia and respiratory tract infection. microscopically large number of round to oval 2-5μm cryptosporidial organisms were found to be lodged on the parabronchial epithelial cells of the respiratory tract. the bacterial colonies were seen around the parabronchial spaces of the lung tissue. i...

In this study, the pathogenicity of A/Ch/It/5093/1999 H7N1 which had been isolated from chicken during the outbreak in Italy was assessed in chicken by experimental infection virus. Ten SPF chickens of four week-old were inoculated with this virus, and five chickens were inoculated with uninfected allantoic fluid. For determination of virus shedding, oropharyngeal and cloacal swabs were taken f...

Abstract We currently lack a complete understanding of the immune responses required to control Mycobacterium tuberculosis (Mtb) infection. Our lab has shown that transcription factor BHLHE40 is essential during Mtb Deletion Bhlhe40 in CD11c +lung macrophages and dendritic cells (DCs) sufficient increase mouse susceptibility infection, though role these infection unknown. Murine bone marrow cul...

aspergillus spp. are ubiquitous saprophytic fungi that cause a variety of diseases, ranging from hypersensitivity reactions to flulike pneumonia and life-threatening invasive aspergillosis. as the lung is the primary site of initial infection with airborne conidia, we investigated the innate immune responses of bronchial epithelial cells against different forms of aspergillus spp.

Forty-one wild sheep (Ovis ammon orintalis) from Kabodan Island of National Park of Urmia Lake (North-West of Iran), were examined during a period of six months from October 2002 to March 2003, for helminthes and coccidian infection. The numbers of oocyst and eggs per gram of faeces (OPG & EPG) were determined by the centrifuge flotation technique using saturated sugar solution. The rate of inf...

Inhalation delivery of aerosolized antibacterials is preferred over conventional methods of delivery for targeting lung infection. The present study is concerned with the development and characterization of a novel, spray dried, aerosolized, chitosan polyelectrolyte complex (PEC) based microparticles containing antibacterials for the treatment of lung infections.Chitosan polyelectrolyte complex...