نتایج جستجو برای: luks pv
تعداد نتایج: 23776 فیلتر نتایج به سال:
presencc of two loci n thc strain A']'CC 497,7S. The first locus consisted of Aig2, tttkS. and fukF (First locus). The second one consistcd oi' tukS-PV and lukFLPV (Second iocus). In a previous study, we demonstrated the presencc of five components, I to V, in S. aureus P83 and identific:d components I, Itl, IV, ttnd V as LukF. LukM, LukS, and Hvll fbr leukocidin and T-ltemolysin, respectively....
OBJECTIVE More than 70% of the community-acquired (CA) staphylococcal infections treated at Texas Children's Hospital are caused by methicillin-resistant Staphylococcus aureus (MRSA). Since September 2002, an increase in the number of severely ill patients with S aureus infections has occurred. This study provides a clinical description of severely ill adolescent patients and an analysis of the...
BACKGROUND Staphylococcus aureus produces several toxins, including Panton-Valentine leukocidin (PVL). The involvement of PVL in primary skin infections, necrotizing pneumonia, musculoskeletal disorders, brain abscess, and other diseases, some of which are life-threatening, has been reported. Following expert opinion, we aimed to provide the tools for establishment of sequence-based diagnostics...
BACKGROUND Staphylococcus aureus produces numerous molecules that facilitate survival in the host. We recently identified a novel S. aureus leukotoxin (leukotoxin GH [LukGH]) using proteomics, but its role in virulence remains unclear. Here we investigated the role of LukGH in vivo. METHODS We tested cytotoxicity of LukGH toward polymorphonuclear leukocytes (PMNs) from mice, rabbits, monkeys,...
Treatment of Staphylococcus aureus infections has become increasingly challenging due to the rise of antibiotic-resistant strains. Therefore, development of antibiotic-independent treatments that supplement or provide an alternative approach to traditional therapies is greatly needed. One promising approach is the development of ‘antipathogenic’ therapies that inhibit bacterial virulence. Quoru...
Staphylococcus aureus strains producing Panton-Valentine leukocidin (PVL) have been epidemiologically linked to specific human infections. To evaluate immunological tests that may be used to diagnose infections with PVL-producing strains, we prospectively collected pus, respiratory tract specimens, and joint fluid specimens from which S. aureus had been isolated in clinical laboratories in six ...
BACKGROUND Toxins are important Staphylococcus aureus virulence factors, but little is known about their immunogenicity during infection. Here, additional insight is generated. METHODS Serum samples from 206 S. aureus-infected patients and 201 hospital-admitted control subjects were analyzed for immunoglobulin (Ig) G binding to 20 toxins, using flow-cytometry based technology. Antibody levels...
OBJECTIVES We performed a 1-year prospective surveillance study on MRSA colonization within the five NICUs of the metropolitan area of Palermo, Italy. The purpose of the study was to assess epidemiology of MRSA in NICU from a network perspective. METHODS Transfer of patients between NICUs during 2014 was traced based on the annual hospital discharge records. In the period February 2014-Januar...
Background. The ratio of CA-MRSA in children with impetigo has been increasing in Japan. Methods. Antimicrobial susceptibilities of 136 S. aureus isolates from children with impetigo were studied. Furthermore, molecular epidemiological analysis and virulence gene analysis were performed. Results. Of the 136 S. aureus isolates, 122 (89.7%) were MSSA and 14 (10.3%) were MRSA. Of the 14 MRSA strai...
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