The type 1 and 8 adenylyl cyclase (ADCY1 ADCY8) exclusively account for Ca 2+ -stimulated cyclic AMP (cAMP) production regulate activity-dependent synaptic modification. In this study, we examined distinct forms of plasticity in the hippocampus Adcy1 −/− Adcy8 mice. We found that, at Schaffer collateral-CA1 synapses, while mice displayed normal long-term potentiation (LTP) following various ind...

  TBS (Theta Burst Stimulation) and PBs (Primed Bursts) are among effective tetanic stimulations for induction of LTP in hippocampus. Recent studies have indicated that TBS is effective in LTP induction in layer III synapses of neocortex, only if applied to layer IV. However, the possibility of neocortical LTP induction using PBs, has not yet been investigated. Sensory deprivation greatly influ...

The effects of chronic morphine administration on the development of long-term potentiation (LTP) were investigated at the Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampal slices using primed-bursts tetanic stimulation. Significant enhancement of orthodromic population spike (OPS) was found for all stimulus intensities after tetanic stimulation. OPS enhancement was greates...

Plasma-derived lipid transfer protein (LTP) facilitates the transfer of cholesteryl ester and triglyceride between all lipoproteins. Kinetic models of the transfer event have suggested that transfer is facilitated through the physical interaction (binding) of LTP with its lipoprotein substrate. Such binding has been observed previously between LTP and high density lipoprotein (HDL), but not bet...

long-term potentiation (ltp) is a reflection of synaptic plasticity that induced by specific patterns of synaptic activity and has an important role in learning and memory. the first clue of the potential role of glutamate receptors in ltp was in 1991 with the observation that the mglur agonists 1-amino-1, 3-cyclopentanedicarboxylic acid (acpd), increased ltp. studies have shown that acpd induc...

introduction: the primary somatosensory cortex has an important role in nociceptive sensory-discriminative processing. altered peripheral inputs produced by deafferentation or by long-term changes in levels of afferent stimulation can result in plasticity of cortex. capsaicin-induced depletion of c-fiber afferents results in plasticity of the somatosensory system. plasticity includes short-term...

記憶はまず海馬で形成された後，脳の他領域に移行する．この時シナプス長期増強現象（LTP）が起こると考えられるが，いつどこで起こるかは明らかではない．そこで光にてLTPを解除する手法を確立し，海馬では学習時にだけではなく，同日の睡眠中にも起こること，大脳皮質では次の日の睡眠中にLTPが起こることを示した．