Several important computer vision tasks have recently been formulated as lowrank problems, with the Low-Rank Representation method (LRR) being one recent and prominent formulation. Although the method is framed as a convex program, available solutions to this program are inherently sequential and costly, thus limiting its scalability. In this work, we explore the effectiveness of a recently int...

Plant immune recognition of pests and pathogens relies on a germline-encoded repertoire innate receptors. In recent years, many examples cell surface receptors in the large gene family receptor-like proteins (RLPs) have been shown to govern specificity. RLPs lack canonical intracellular kinase domain associated with receptor kinases, but instead transduce signaling through interactions co-recep...

Nucleotide-binding site and leucine-rich repeat (NBS-LRR) genes represent the largest and most important disease resistance genes in plants. The genome sequence of the common bean (Phaseolus vulgaris L.) provides valuable data for determining the genomic organization of NBS-LRR genes. However, data on the NBS-LRR genes in the common bean are limited. In total, 178 NBS-LRR-type genes and 145 par...

Slit is a repellent axon guidance cue produced by the midline glia in Drosophila that is required to regulate the formation of contralateral projections and the lateral position of longitudinal tracts. Four sequence motifs comprise the structure of Slit: a leucine-rich repeat (LRR), epidermal growth factor-like (EGF) repeats, a laminin-like globular (G)-domain, and a cysteine domain. Here we de...

The phytopathogenic bacterium Ralstonia solanacearum encodes type III effectors, called GALA proteins, which contain F-box and LRR domains. The GALA LRRs do not perfectly fit any of the previously described LRR subfamilies. By applying protein sequence analysis and structural prediction, we clarify this ambiguous case of LRR classification and assign GALA-LRRs to CC-LRR subfamily. We demonstrat...

Polycystin-1, the product of the PKD1 gene, is a membrane-bound multidomain protein with a unique structure and a molecular weight of approximately 460 kD. The purpose of this study is to investigate the binding of the cystein-flanked leucine-rich repeats (LRR) of polycystin-1 to extracellular matrix (ECM) components. These interactions may play a role in normal renal development as well as the...

The low-rank representation (LRR) was presented recently and showed effective and robust for subspace segmentation. This paper presents a LRR-based discriminative projection method (LRR-DP) for robust feature extraction, by virtue of the underlying low-rank structure of data represesntation revealed by LRR. LRR-DP seeks a linear transformation such that in the transformed space, the betweenlarg...

Plant nucleotide-binding (NB) and leucine-rich repeat (LRR) receptors mediate effector-triggered immunity. Two major classes of NB-LRR proteins are involved in this process, namely, toll-interleukin receptor (TIR)-NB-LRR and coiled coil (CC)-NB-LRR proteins. Recent reports show that some of the TIR-NB-LRRs and CC-NB-LRRs localize to the cytoplasm and nucleus. Equilibrium between these pools is ...

PURPOSE To evaluate the risk of locoregional recurrence (LRR) associated with locoregional treatment of women with primary breast cancer tumors negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (triple-negative breast cancer [TNBC]). PATIENTS AND METHODS Patients diagnosed with TNBC were identified from a cancer registry in a single institutio...

PURPOSE To identify genes predicting benefit of radiotherapy in patients with high-risk breast cancer treated with systemic therapy and randomized to receive or not receive postmastectomy radiotherapy (PMRT). EXPERIMENTAL DESIGN The study was based on the Danish Breast Cancer Cooperative Group (DBCG82bc) cohort. Gene-expression analysis was performed in a training set of frozen tumor tissue f...