Septicaemia caused by gram-negative pathogens is a dangerous infection which is associated with high incidence of liver dysfunction. The severe and acute hepatotoxicity is presumably due to massive release of endotoxin into systemic circulation after bacterial killing. The direct toxic effect of endotoxin is probably due to the increased production of reactive oxygen intermediates as O 2 - , p...

nigella sativa (ns) ( ranunculaceae ) used as a protective and therapeutic traditional medicine. this study evaluates the effect of ns on inflammation-induced myocardial fibrosis, serum and tissue inflammatory markers, and oxidative stress status in male rats. fifty male wistar rats were divided into five groups: (1) control; (2) lipopolysaccharide (lps), 1 mg/kg/day; (3) lps + ns (hydroalcohol...

Introduction: Based on the documents in traditional medicine regarding the therapeutic effect of Sour orange flowers (Citrus aurantium L.) on the nervous system disorders, this experimental study was conducted to evaluate the pretreatment of Sour orange flowers extract in preventing or reducing depressive-like behaviors induced by systemic injection of lipopolysaccharide (LPS) in rats. Method: ...

Objective: Stressors have an important role in sickness behaviors. We checked the effect of Zataria multiflora (ZM) extract against lipopolysaccharide (LPS)-induced anxiety and depression behaviors in rats. Material and Methods: Rats were distributed in the following groups (n=10): Control, LPS (1 mg/kg), LPS-ZM50, LPS-ZM100 and LPS-ZM200. LPS was syringed intraperitoneally (ip) 2 hr bef...

Introduction: In the present study, the effect of an inducible NO synthase (iNOS) inhibitor, aminoguanidine (AG) on lipopolysaccharide (LPS)-induced memory impairment and oxidative stress and inflammation parameters was evaluated. Materials and Methods: The rats were divided into 5 groups and treated: 1) Control (Saline), 2) LPS (1 mg/kg), 3-5) AG 50, 100 and 150mg/kg 30 min before LPS injectio...

Purpose: To study the protective influence of baicalin (BA) against LPS-mediated acute lung injury (ALI) in a rat model.
 Methods: Twenty-seven Sprague-Dawley (SD) rats were assigned (9 each) to groups as follows: normal control (NC) treated intraperitoneally with saline; lipopolysaccharide (LPS) group 10 mg/kg LPS; and (LPS + Ba) 100 LPS, followed 15 min later by baicalin. Pathological ch...

The present study investigated the effects of E. coli lipopolysaccharide (LPS) induced mastitis model in rat on the activity of antioxidant enzyme systems. To achieve this purpose, E. coli LPS were infused into the mammary gland of 12 rats 72 hr postpartum and compared with 12 rats in control group infused intramammary placebo sterile pyrogene – free, physiological saline. The...

The aim of the present study was to investigate effects diammonium glycyrrhizinate lipid ligand (DGLL) treatment on acute lung injury (ALI) and pulmonary edema induced by lipopolysaccharide (LPS) in Sprague?Dawley rats. Rats orally received 30, 60 120 mg/kg DGLL. After 1 h, rat ALI model established LPS (10 mg/kg) intraperitoneal injection. 6 evaluated using hematoxylin eosin staining technique...

Lipopolysaccharide (LPS) was used to induce neuroinflammation in rats and the expression of brain cyclooxygenase-2 (COX-2) is marker for process [1]. The effect minocycline on neuroinflammation-induced LPS not clearly elucidated.
 
 objective this study determine effects (MIN) LPS-induced COX-2 compared it with a clinically approved drug Alzheimer’s disease named memantine. A total fi...

Objective(s): The aim of current study was to evaluate improving effects of pioglitazone as an agonist of peroxisome proliferator-activated receptor gamma (PPARγ), on brain-derived neurotrophic factor (BDNF) and cytokines as well as tissue oxidative damage criteria in the hippocampus in a rat model of lipopolysaccharide (LPS) induced memory impairment.<strong...