نتایج جستجو برای: lox isolation

تعداد نتایج: 133969  

Journal: :European heart journal 2014
Alexander Akhmedov Izabela Rozenberg Francesco Paneni Giovanni G Camici Yi Shi Carola Doerries Anna Sledzinska Pavani Mocharla Alexander Breitenstein Christine Lohmann Sokrates Stein Tobias von Lukowicz Michael O Kurrer Jan Borén Burkhard Becher Felix C Tanner Ulf Landmesser Christian M Matter Thomas F Lüscher

AIMS Lectin-like oxLDL receptor-1 (LOX-1) mediates the uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells and macrophages. However, the different atherogenic potential of LOX-1-mediated endothelial and macrophage oxLDL uptake remains unclear. The present study was designed to investigate the in vivo role of endothelial LOX-1 in atherogenesis. METHODS AND RESULTS Endotheli...

Journal: :Hypertension 2008
En-Hui Yao Noboru Fukuda Takahiro Ueno Hiroyuki Matsuda Koichi Matsumoto Hiroki Nagase Yoshiaki Matsumoto Ayako Takasaka Kazuo Serie Hiroshi Sugiyama Tatsuya Sawamura

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a membrane protein that can support the binding, internalization, and proteolytic degradation of oxidized low-density lipoprotein. The LOX-1 expression increases in the neointima after balloon injury. To develop an efficient compound to inhibit LOX-1, we designed and synthesized a novel gene silencer pyrrole-imidazole (PI) polya...

Journal: :Plant physiology 1999
K Matsui K Hijiya Y Tabuchi T Kajiwara

In cucumber (Cucumis sativus), high lipoxygenase-1 (LOX-1) activity has been detected in the soluble fraction prepared from cotyledons of germinating seeds, and the involvement of this enzyme in lipid turnover has been suggested (K. Matsui, M. Irie, T. Kajiwara, A. Hatanaka [1992] Plant Sci 85: 23-32; I. Fuessner, C. Wasternack, H. Kindl, H. Kühn [1995] Proc Natl Acad Sci USA 92: 11849-11853). ...

Journal: :Investigative ophthalmology & visual science 2015
Cui Li Guiqiu Zhao Chengye Che Jing Lin Na Li Liting Hu Nan Jiang Ying Liu

PURPOSE To determine the role of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) in corneal epithelial cells exposed to fungus. METHODS Thirteen corneas with fungal keratitis composed the experimental group. Ten healthy donor corneas were the control group. Corneal epithelium was scraped and LOX-1 mRNA tested. Immunostaining was used to detect LOX-1 protein. Human corneal epit...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2000
T Murase N Kume H Kataoka M Minami T Sawamura T Masaki T Kita

Lectin-like oxidized LDL receptor-1 (LOX-1) is a type II membrane protein belonging to the C-type lectin family molecules, which can act as a cell-surface endocytosis receptor for atherogenic oxidized LDL. In this study, we show that soluble forms of LOX-1 are present in conditioned media of cultured bovine aortic endothelial cells (BAECs) and CHO-K1 cells stably transfected with LOX-1 cDNA. Im...

Journal: :Oncology reports 2014
Ying Zheng Xuemei Wang Haidong Wang Wei Yan Quan Zhang Xin Chang

Lysyl oxidase is an important extracellular matrix remodeling enzyme and plays critical roles in tumor progression and development. Its tumor-suppressor activity has been shown to depend on the propeptide region. Previous studies have reported that the expression levels of lysyl oxidase propeptide (LOX-PP) are associated with cancer of the breast, pancreas, lung, prostate and gastrointestinal s...

Journal: :Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2017
Yoon Se Lee Yangsoon Park Minsu Kwon Jong-Lyel Roh Seung-Ho Choi Soon Yuhl Nam Sang Yoon Kim

Objective To investigate the prognostic significance of lysyl oxidase (LOX) expression in laryngeal cancer. Study Design Retrospective chart review and histologic analysis. Setting Tertiary referral academic center. Subjects and Methods Patients (N = 100) underwent surgical treatment for laryngeal cancer and had tissue specimens available. Immunohistochemical staining for LOX was performed on l...

Journal: :Cancer research 2007
Min Wu Chengyin Min Xiaobo Wang Ziyang Yu Kathrin H Kirsch Philip C Trackman Gail E Sonenshein

The gene encoding lysyl oxidase (LOX) was identified as the ras recision gene (rrg), with the ability to revert Ras-mediated transformation of NIH 3T3 fibroblasts. Mutations in RAS genes have been found in approximately 25% of lung cancers and in 85% of pancreatic cancers. In microarray analysis, these cancers were found to display reduced LOX gene expression. Thus, the ability of the LOX gene ...

2016
Raveendra Aanangi Kasi Viswanath Kotapati Bhagath Kumar Palaka Thyagaraju Kedam Nirmala Devi Kanika Dinakara Rao Ampasala

This study reports purification and characterization of lipoxygenase protein from mung bean germinating seedlings. Lipoxygenases (LOXs) are key enzymes in seed germination. The purified mung bean LOX has resolved into two peaks by chromatofocusing, one has highest LOX activity with an isoelectric point of 5.84 and the other has lowest LOX activity with an isoelectric point of 5.52. The purified...

Journal: :Cancer research 1998
D Nie G G Hillman T Geddes K Tang C Pierson D J Grignon K V Honn

Previously, we found a positive correlation between the expression of platelet-type 12-lipoxygenase (12-LOX) and the progression of human prostate adenocarcinoma (PCa; Gao et al., Urology, 46: 227-237, 1995). To determine the role of 12-LOX in PCa progression, we generated stable 12-LOX-transfected PC3 cells, which synthesize high levels of 12-LOX protein and 12(S)-hydroxyeicosatetraenoic acid ...

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