Hydrochlorothiazide (HCT) is a thiazide diuretic which reduces the resorption of electrolytes and consequently of water. Enalapril maleate (EM) is a derivative of 2 amino acids, L-alanine and L-proline, and is an antihypertensive and a vasodilator in congestive heart failure. The 2 drugs are used in association in the treatment of hypertension . Several methods are available in the literature f...

A biologically active vitamin D(3) metabolite ("peak V metabolite") more polar than 25-hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono(trimethylsilyl)ether derivative. The molecule has been identified as 1,25-dihydroxycholecalciferol by means of mass spectrometry, ultraviolet absorption spectrophotometry, and specific chemical reactions.

A new sensitive, simple, rapid and precise method for simultaneous estimation of paracetamol and aceclofenac in combined tablet dosage form has been developed. The method is based on ratio derivative spectrophotometry. The amplitude in first derivative of the ratio spectra at 256 nm and 268 nm (minima) were selected to determine paracetamol and aceclofenac in combined formulation. The method sh...

Two methods for simultaneous estimation of hydrochlorothiazide and olmesartan medoxomil in combined tablet dosage form have been developed. The first method is the application of Q-analysis method (absorbance ratio), which involves the formation of Q-absorbance equation at 264 nm (isobestic point) and at 271 nm, the maximum absorption of hydrochlorothiazide. The linearity ranges for hydrochloro...

in this study, different derivative spectrophotometric methods are proposed for the simultaneous determination of chlorpheniramine maleate (cp), phenylephrine hcl (pe) and phenylpropanolamine hcl (pp) in their ternary mixtures and in pharmaceutical dosage forms. spectra of single component and ternary mixtures of various concentrations and combinations from zero- to fourth-derivation were obtai...

In this study, zero-, first-, secondand third-order derivative spectrophotometry methods were developed for the determination of metoprolol in pharmaceutical preparations. In zero order spectrophotometry, absorbance values were measured at 276 nm in zero order spectra of solution of metoprolol in methanol in the range of 240-310 nm. In first derivative spectrophotometry, absorbance values were ...