Rapid place encoding by hippocampal neurons, as reflected by place-related firing, has been intensely studied, whereas the substrates that translate hippocampal place codes into behavior have received little attention. A key point relevant to this translation is that hippocampal organization is characterized by functional-anatomical gradients along the septotemporal axis: Whereas the ability of...

BACKGROUND/RATIONALE Guided by the need-driven dementia-compromised behavior (NDB) model, this study examined influences of the physical environment on wandering behavior. METHODS Using a descriptive, cross-sectional design, 122 wanderers from 28 long-term care (LTC) facilities were videotaped 10 to 12 times; data on wandering, light, sound, temperature and humidity levels, location, ambiance...

1 Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Callinstrasse 38, D-30167 Hannover, Germany 2 ESTEC, Noordwijk, The Netherlands 3 Astrium GmbH, 88039 Friedrichshafen, Germany 4 Department of Physics and Astronomy, University of Glasgow, Glasgow, UK 5 Rutherford Appleton Laboratories, Chilton, UK 6 University of Birmingham, Birmingham, UK 7 Universität Hannover, Institut...

AIMS To develop and evaluate the psychometric properties of a Chinese Feeding Difficulty Index (Ch-FDI) which assesses feeding difficulties in people with dementia (PwD). RESEARCH DESIGN AND METHOD Scale items were developed using literature review based on Model of Feeding Difficulty. Content validity was evaluated and items were modified by expert panel. Following translation and back-trans...

conclusions the stereotactic brachytherapy for patients with circumscribed and relatively small size tumors appears to be a safe, feasible, and minimally-invasive treatment. results thirteen patients were male and 16 were female, with the median age of 29 years (range, 2.5 – 64 years). the median follow-up was 95 (range, 6 – 240) months. based on pignatti classification, 10 patients were at low...

introduction: stress is associated with neurological and cognitive disorders. it has been suggested that doxepin, in addition to its influence on the content of neurotransmitters, has probable neuroprotective effects as well. therefore, the aim of this study was to investigate the effects of doxepin on synaptic plasticity and brain-derived neurotrophic factor (bdnf) gene expression in the rat h...

long-term potentiation (ltp) is a reflection of synaptic plasticity that induced by specific patterns of synaptic activity and has an important role in learning and memory. the first clue of the potential role of glutamate receptors in ltp was in 1991 with the observation that the mglur agonists 1-amino-1, 3-cyclopentanedicarboxylic acid (acpd), increased ltp. studies have shown that acpd induc...

The term synaptic plasticity points to a series of persistent changes related to the activity of synapses. Long-term potentiation (LTP) is a reflection of synaptic plasticity that has an important role in learning and memory. LTP is a long-lasting increase of synaptic activity due to enhancement of excitatory synaptic transmission after a high-frequency train of electrical stimulations. Differe...