While most obstetricians are familiar with fracture of the clavicle in newborns during birth, an unlucky minority of obstetricians has encountered long-bone fractures in newborns as well. This complication is traumatic not only for the neonate, but also for the family and the obstetrician; it is also difficult to explain. Fortunately, the long-term prognosis for fracture of the long bones is ex...

Angiogenesis is an important step in bone fracture healing. In this article, we report on the healing of long bone fractures, and the involvement of the vascular and the inflammatory systems in the process. We conducted a prospective study of 20 healthy adults with traumatic long bone fracture. One week after fracture, and then 1 month later, we evaluated markers of inflammation: vascular respo...

Renal cell carcinoma (RCC) is an aggressive malignancy which can metastasize to the bone. Long bones or the small bones of the limbs could be rarely the destinations for metastatic RCCs. We report two cases of metastatic RCC to the humerus bone with the initial presentation of pathological fracture. The pathologists must be aware of metastatic RCC to the arm and consider it in the differential ...

Background: The purpose of this retrospective study was to analyze the long-term results of revision ORIF, jointcontracture release, and autogenous bone-grafting in the treatment of distal humerus frac-ture nonunions in older agedpatients with poor bone quality or bone loss who would have been candidates for total elbow arthroplasty.Methods: Seven patients (average age at inde...

Bisphosphonates (BPs) have been in use for many years for the treatment of osteoporosis, multiple myeloma, Paget's disease, as well as a variety of other diseases in which there is reduced bone mineral density. Given that bisphosphonates inhibit bone resorption, an important stage of fracture healing; this class of compounds has been widely studied in preclinical models regarding their influenc...

BACKGROUND We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts. METHODS Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast inje...

Bone fractures are among the common disorders worldwide. The healing process of a fracture is a relatively long period. Furthermore, a significant portion of fractures become nonunions or delayed that increase the long healing process of fractures even more. These characteristics have provoked the researchers to develop new techniques for reducing the healing process of fresh bone fracture as w...

Electric potentials generated by mechanical strain of bones (SGPS: strain generated potentials) are one of the cofactors, which determine the adaptive remodelling processes in bone tissue [1,12,14]. The significance of the potentials SGPs in bone tissue biodynamics results from the electrosensivity of bone cells membranes via the Ca voltage-gated channels [7], Fig.1a. Bioelectric signals are al...

Fracture healing is a complex process in which mechanical forces are essential for the regeneration of bone tissue. Mechanical loading can induce osteogenesis through the process of mechanotransduction. Current data on how mechanical loading stimulates fracture healing in weight-bearing long bones are presented. The role of mechanosensors, loading-induced interstitial fluid flow, streaming pote...

BACKGROUND S100B is an acknowledged marker of brain damage. However, trauma without brain damage also causes an increase in S100B. S100B concentrations are highest in multiple trauma patients with long bone fractures. Clinically, extensive long bone fractures are associated with haemorrhagic shock and haemorrhagic shock per se is associated with increased S100B. The aim of our experimental stud...