Genetic screens have been widely applied to uncover genetic mechanisms of movement disorders. However, most screens rely on human observations of qualitative differences. Here we demonstrate the application of an automatic imaging system to conduct a quantitative screen for genes regulating the locomotive behavior in Caenorhabditis elegans. Two hundred twenty-seven neuronal signaling genes with...

Time-lapse videotape recordings of polymorphonuclear leukocytes (PMNs) from clot preparations were used to quantify the locomotive behavior of individual PMNs from normal subjects. Tracings derived from the videotapes allow one to quantify multiple parameters of the locomotive behavior of PMNs--direction, distance, rate, and angle of turn. The results obtained are reproducible from subject-to-s...

In today's design, system complexity and increasing demand for safer, more efficient and less costly systems have created new challenges in science and engineering. Locomotives are products which are designed according to market order and technical needs of customers. Accordingly, targets of companies, especially designers and manufacturers of locomotives, have always been on the path of progre...

An autonomous control methodology is proposed for locomotive agents to have lifelike personified behaviors. The control introduces a pattern generator that is constructed by connecting oscillators composed of mutually inhibited neurons. The rhythmic signal of the pattern generator drives a proportional derivative controller that determines the legs joint angles of a locomotive agent, and the si...

Fuel spillage during locomotive refueling is expensive, as is maintaining spill collection and containment systems, and waste treatment costs. The Association of American Railroads has developed the first standard for a locomotive refueling system for North American railroads. The locomotive fueling interface standard is an open, non-proprietary standard designed to prevent fuel spillage. Proto...