Background and Aim: Local anesthetic injection is among the most anxiety-provoking procedures in children. Some scales are currently available to quantify the level of pain experienced based on the child’s behavior. The purpose of this study was to compare two commonly used pain scales. Materials and Methods: This split-mouth study was conducted on 49 healthy children aged 3.5 to 9 years who n...

I T seems implausible that an injection of a simple, off-theshelf, intravenous nutritional solution could be acutely life-saving for a patient with severe drug overdose. But dozens of published case reports support this observation, first made more than a decade ago in a rodent model of bupivacaine toxicity. It is even more surprising that such a simple formulation can rapidly reverse severe cl...

genetic manipulation in mice is becoming more feasible and affordable. An important part of mouse husbandry is euthanasia, which should be performed as painlessly and efficiently as possible. There are several ways in which laboratory mice are euthanized, two of which include carbon dioxide (CO2)induced asphyxia and cervical dislocation. CO2 overdose has been favored for euthanasia, because the...

HANNAH Greener of Winlaton, near Newcastle in the United Kingdom, died more than 150 yr ago, on January 28, 1848, after receiving a chloroform anesthetic for the removal of a toenail. She was a healthy 15-yr-old girl who had successfully undergone an anesthetic with diethyl ether several months before for the removal of another toenail. Hers was the first death (fig. 1) attributed to the new an...

Article| August 2023 Closed Claims Case Review 2023-8: Making Sense of Local Anesthetic Systemic Toxicity ASA Monitor 2023, Vol. 87, 33–34. https://doi.org/10.1097/01.ASM.0000949616.89467.de Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Share Facebook Twitter LinkedIn Email Cite Get Permissions Search Site Citation Toxicity. 2023; 87:33–34 doi: Download citati...

Introduction: Although patients do not experience sever pain after laparoscopic surgery, most of them experience acute or chronic pain afterward. While conventional pain killers including NSAID and narcotics in laparoscopic surgery have specific side effects, their application is inevitable. This study compares the efficacy of local anesthetic drugs and conventional pain killers in post-operati...