A 56-year-old woman with sickle-cell trait (hemoglobin electrophoresis with 53.5% hemoglobin A, 3.7% hemoglobin A2, 41.7% hemoglobin S and 1.1% hemoglobin F) was seen for recurrent episodes of ‘bilateral’ flank pain associated with gross hematuria and passage of cellular debris. These episodes had occurred on an infrequent basis for many years and seemed to be triggered by fasting. Her past med...

1. A procedure is described by which several protein constituents may be obtained from extracts of lobster claw nerves. One of these fractions, designated fraction A, representing 10 per cent of the total non-dialyzable material of the extracts, has been obtained in relatively (85 per cent) pure form. 2. This component has been characterized with respect to its physicochemical properties, parti...

Bilateral asymmetry of the paired claws of the lobster Homarus americanus is determined during the fourth and fifth juvenile stages by differential reflex activity; the side with the greater activity becomes the crusher while the contralateral side becomes the cutter. Juvenile lobsters reared during this critical period with a substratum that could not be grasped or with reduced input from pred...

Lobster claw muscles undergo a process of fiber switching during development, where isomorphic muscles containing a mixture of both fast and slow fibers, become specialized into predominantly fast, or exclusively slow, muscles. Although this process has been described using histochemical methods, we lack an understanding of the shifts in gene expression that take place. In this study, we used s...

Received; 08.10.2014; Revised: 20.05.2015; Accepted: 02.06.2015 A 36 years old male presented in medicine outpatient department of our hospital with episode of generalized tonic-clonic seizures. History and clinical examination revealed that he was born with deformed hands and feet in the form of absent middle finger in both the upper limbs and syndactyly of great toe and 2nd toe with absence o...

Split-hand deformity is one of the milder manifestations of a congenital disorder called split-hand/split-foot malformation. We present a case of a 4-year-old child with split-hand malformation in his left hand since birth. A median cleft was present in the affected hand with absence of the 3rd and 4th digits, giving rise to a characteristic lobster-claw appearance. Functionality of the affecte...

Ectrodactyly is an autosomal dominant ectodermal dysplasia presenting as bilateral congenital malformed hands and feet [1]. It affects about 1 in 90,000 births with males and females equally as likely to be affected. It is characterized by transverse terminal aphalangia or partial to total absence of the distal segments of fingers. It may involve one or more digits or the full hand and even par...

The split hand/split foot malformation (SHFM), which is also known as ectrodactyly, is a limb malformation syndrome involving the central rays of the hand or foot. The typical SHFM may present with syndactyly; median clefts of the hands and feet; and aplasia or hypoplasia (or both) of the phalanges, metacarpals, and metatarsals. Numerous human gene defects can cause SHFMs. For example, the SHFM...