The structure of supergiant shells, in particular of LMC 4, is hard to explain with stochastic selfpropagating star formation. A series of supergiant structures lies along the outer edge of the LMC and form a sequence increasing clockwise in age. We have considered the rotation of the LMC and its motion through the halo of the Milky Way and propose that these structures find their origin in sta...

Motor neurons (MNs) are unique because they project their axons outside of the CNS to innervate the peripheral muscles. Limb-innervating lateral motor column MNs (LMC-MNs) travel substantially to innervate distal limb mesenchyme. How LMC-MNs fine-tune the balance between survival and apoptosis while wiring the sensorimotor circuit en route remains unclear. Here, we show that the mir-17∼92 clust...

Motoneuron survival in the embryonic spinal cord is influenced by the presence or absence of the developing limb bud. We have recently begun a reexamination of the relationship between limb absence and motoneuron survival in a nonsurgical limb deletion model, the limbless mutant chick embryo. As in surgically limb-deleted normal embryos, only 10% of the motoneurons that are initially produced i...

Although a decade of microlensing searches towards the Large Magellanic Cloud (LMC) has detected 13− 25 possible microlensing events, the nature and the location of the lenses, being either halo machos or LMC stars, remains a subject of debate. The star-star lensing models generically predict the existence of a small population (more than ∼ 5%) of stars with a spatial and kinematic distribution...

We present a detailed study of the viewing angles and geometry of the inner LMC ( P 4 ) based on a sample of more than 2000 MACHO Cepheids with complete {VR}KC light curves and single-phase Two Micron All Sky Survey (2MASS) JHKs observations. The sample is considerably larger than any previously studied subset of LMC Cepheids and has an improved areal coverage. Single-epoch random-phase 2MASS p...

Loss of mesodermal competence (LMC) during Xenopus development is a well known but little understood phenomenon that prospective ectodermal cells (animal caps) lose their competence for inductive signals, such as activin A, to induce mesodermal genes and tissues after the start of gastrulation. Notch signaling can delay the onset of LMC for activin A in animal caps [Coffman, C.R., Skoglund, P.,...

We investigate the present distributions of gas and young stars in the Large and Small Magellanic Clouds (LMC and SMC) based on fully self-consistent numerical simulations of the Clouds for the last ∼ 0.8 Gyr. Our principal results, which can be tested against observations, are as follows. The last dynamical and hydrodynamical interaction between the Clouds about ∼ 0.2 Gyr ago can form the appa...

The laryngeal motor cortex (LMC) is indispensible for the vocal motor control of speech and song production. Patients with bilateral lesions in this region are unable to speak and sing, although their nonverbal vocalizations, such as laughter and cry, are preserved. Despite the importance of the LMC in the control of voluntary voice production in humans, the literature describing its connection...

The microlensing surveys towards the Large Magellanic Cloud (LMC) have demonstrated the existence of compact objects that act as gravitational lenses somewhere between us and LMC. Besides the 4 events found by the EROS2 group [1], the MACHO Project has detected 16 events and its maximum likelihood estimate of the mass of the lensing objects is ≈ 0.5 M⊙, while the fraction f of dark matter in fo...

We have reanalyzed the Large Magellanic Cloud's (LMC) ultraviolet (UV) extinction using data from the IUE final archive. Our new analysis takes advantage of the improved signal–to–noise of the IUE NEWSIPS reduction, the exclusion of stars with very low reddening, the careful selection of well matched comparison stars, and an analysis of the effects of Galactic foreground dust. Differences betwe...