Aim: The aim of this study was to formulate and evaluate liquisolid compact system of carvedilol to give increased dissolution rate of drug by utilizing PEG400 as the non-volatile liquid vehicle. Materials and Methods: The liquisolid tablets formulated with PEG400 at different concentrations. The suitable analytical method based on UV-visible spectrophotometer was developed for carvedilol. Resu...

Lovastatin is a poorly soluble, BCS class II drug belonging to the category of anti-hyperlipidemics having poor bioavailability (<5%).The present study is designed to enhance the dissolution rate and bioavailability of Lovastatin by Liquisolid compacts and to evaluate the effect of carriers on drug dissolution rates. Lovastatin Liquisolid tablets were prepared by using different carriers namely...

PURPOSE: For poorly soluble, highly permeable (Class II) drugs, such as indomethacin, the rate of oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. Therefore together with the permeability, the solubility and dissolution behaviour of a drug are key determinants of its oral bioavailability. The object of the present study is to increase dissolution rate o...

Liquisolid compacts were used to formulate water insoluble drugs in non-volatile solvents and converting into acceptably flowing and compressible powders. The main objective of present investigation was to enhance the dissolution rate of water insoluble drug ketoprofen by using liquisolid technique. Several liquisolid tablets were prepared by using different carrier materials such as microcryst...

This study was carried out to evaluate the absorption characteristics of experimentally developed hydrochlorothiazide liquisolid tablets using six male beagle dogs. Comparison with reference commercial tablets was made. As no bibliographic data were found for the pharmacokinetic parameters of the drug in dogs, an intravenous drug administration was included in the study. The drug was administer...

the potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. in this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. it is worth mentio...

The current investigation was used to improve the rate of dissolution an anti-diarrheal drug i.e., racecadotril (RT) at low pH conditions (i.e., in stomach) by reducing water secretion and electrolyte intestine liquisolid tablets. Different formulations (liquisolid) were prepared using Avicel PH 102 as a carrier. Aerosil 200 coating material sodium starch glycolate disintegrant. Polyethylene gl...

Liquisolid systems are a novel, promising platform for the production of solid dosage forms with high liquid content, i.e. dispersion drug in suitable, hydrophilic, non-volatile vehicle or drug. This technology requires conventional, but highly porous excipients (carrier and coating material appropriate ratio) able to absorb/adsorb medication, resulting both good flowability acceptable compress...