The aim of our study was to improve the availability of Rofecoxib a practically insoluble non-steroidal anti-inflammatory drug, as a model drug by using liquisolid technique. The effect of powder substrate composition on the flowability and compressibility of liquisolid compacts were evaluated. Specifically, several liquisolid formulations, containing 25-mg Rofecoxib, which containing different...

The purpose of the present research was to study the effects of Ceolus KG-802 on the dissolution behavior of fenofibrate liquisolid tablets. The fenofibrate liquisolid tablets were formulated using the mathematical model described by Spireas et al. In the present research, Ceolus KG-802, a different form of microcrystalline cellulose (PH 102 grade), was used as a carrier material. The developed...

A liquisolid system has the ability to improve the dissolution properties of poorly water soluble drugs. Liquisolid compacts are flowing and compactable powdered forms of liquid medications. The aim of this study was to enhance the in vitro dissolution properties of the practically water insoluble loop diuretic furosemide, by utilising liquisolid technique. Several liquisolid tablets were prepa...

The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. It is worth mentio...

The current investigation was used to improve the rate of dissolution an anti-diarrheal drug i.e., racecadotril (RT) at low pH conditions (i.e., in stomach) by reducing water secretion and electrolyte intestine liquisolid tablets. Different formulations (liquisolid) were prepared using Avicel PH 102 as a carrier. Aerosil 200 coating material sodium starch glycolate disintegrant. Polyethylene gl...

Abstract: Background: Artemether is a potent antimalarial drug used in the first-line treatment of multi-drug-resistant malaria. It belongs to BCS II, exist different polymorphic forms, and exhibits incomplete absorption low oral bioavailability owing poor dissolution. Aim: The present study evaluates effect mesoporous materials liquisolid compact for augmentation dissolution drug, stability. M...