Modern trends in the reduction of cigarette consumption have led to spread smokeless tobacco and non-tobacco nicotine-containing products [1]; their variety creates certain problems with identification this segment. Sucking (snus) has been banned Russian Federation for wholesale retail trade since 2015, but it is a product similar chew- ing packaging, ingredient composition physiological effect...

Highly active cytochrome b6f complexes from spinach and the cyanobacterium Mastigocladus laminosus have been analyzed by liquid chromatography with electrospray ionization mass spectrometry (LCMS ). Both sizeexclusion and reverse-phase separations were used to separate protein subunits allowing measurement of their molecular masses to an accuracy exceeding 0.01% ( 3 Da at 30,000 Da). The produc...

Zucker Diabtic Fatty rats is a common model used for the studies related to type 2 diabetes. Metabolomics, proven by previous studies, can be prediction of phenotype. This investigation held untargeted metabolomics analysis on serum metabolites Diabetic rats, intended gain insights in study pathology LCMS method (liquid chromatography coupled with mass spectrometry) an analytical chemistry tech...

hibitors used to treat human immunodeficiency virus (HIV)1. Tenofovir can be administered once-daily at a dose of 300 mg in combination with other antiretroviral drugs. The advantage of once-daily dosing is a reduction in patient drug load. Also, tenofovir appeared to be well tolerated with low rates of drug-related therapy discontinuation in several clinical trials. Thus, tenofovir use is expe...

Liquid chromatography combined with electrospray ionization is widely used for direct analysis of polar and labile molecules by LCMS. The on-line coupling in LCMS is a major strength but also causes a principal limitation that each eluting analyte has to be analyzed immediately and is not available for detailed interrogation after the LCMS run. Here we developed a new chromatographic strategy, ...

Liquid chromatography-mass spectrometry (LC-MS, or alternatively HPLC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry. LCMS is frequently used in drug development at many different stages including Peptide Mapping, Glycoprotein Mapping, Natural Products Derepli...

Liquid chromatography tandem mass spectrometry (LCMS/MS) has been combined with different sample preparation strategies to determine potential pesticide residues existing in wine. Herein, we propose the on-line coupling between solid-phase extraction (SPE), based on a reversed-phase polystyrene-divinyl benzene (PS-DVB) sorbent, and LCMS/MS for automated monitoring of selection 48 pesticides (37...

The popular use of ciprofloxacin is often irrational, so it causes environmental pollution such as resistance. solution to overcome due degradation by using TiO2 nanoparticles. nanoparticles performance influenced environment light source, pH solvent, duration lighting and mass. residual levels determination was carried out a UV-Vis spectrophotometer. Toxicity test products with used Escherichi...