The ether à go-go1 (Eag1) channel is overexpressed in a variety of cancers. However, the expression and function of Eag1 in liposarcoma are poorly understood. In the present study, the mRNA expression of Eag1 in different adipose tissue samples was examined by real-time PCR. Then, the protein expression of Eag1 in 131 different adipose tissues from 109 patients was detected by immunohistochemis...

BACKGROUND Molecular mechanism of differentiation in lipogenic tumor is still unknown in detail. Low-density lipoprotein receptor-related protein (LRP) and peroxisome proliferator-activated receptor gamma (PPAR-gamma), representative regulatory molecules of lipogenic differentiation, have been reported today as multi-functional molecules and to modulate tumorigenesis in various kind of cancer. ...

A unique case of primary myxoid liposarcoma of the thigh, in which focal pleomorphic areas were present containing rhabdomyoblasts, is described. Focal rhabdomyosarcoma in liposarcoma has only rarely been reported previously and only in dedifferentiated liposarcomas of the retroperitoneum. All but one have been recurrences with rhabdomyoblasts being absent in the primary liposarcoma. As rhabdom...

PURPOSE To describe a patient with liposarcoma metastatic to the left orbit. METHODS A 72-year-old man was admitted with diplopia and proptosis of the left eye. Previously, a retroperitoneal liposarcoma had been surgically removed followed by postoperative radiation. Visual acuity was normal. There was proptosis of the left eye, increased retrobulbar resistance and reduced mobility. Trans-sep...

BACKGROUND Liposarcoma most commonly arises in the retroperitoneum and lower extremities. Liposarcoma of the head and neck is rare, with only 12 previously reported cases of liposarcoma in the tongue. CASE PRESENTATION We present a case of well-differentiated liposarcoma of the tongue occurring in a 39 year old man, treated with surgical excision. At 14 years of follow-up, the patient remains...

Liposarcoma is the most common malignant soft tissue tumor in adults. Extremities and retroperitoneum are sites of involvement liposarcoma. gastrointestinal tract rare colon an extremely uncommon site. Mesenchymal tumors bowel mainly represented by stromal (GIST). A sixty-one-year-old male patient presented with abdominal pain distension. Contrast-enhanced computerized tomography (CECT) showed ...

spermatic cord liposarcomas are very rare tumors. patients usually present with painless growing scrotal swellings which are clinically misdiagnosed as hernia. the correct diagnosis is not common and usually they present as operative or histological surprises. to our knowledge, there are about 186 similar cases reported in the literature. herein we report three cases of spermatic cord liposarco...

Background & Objective: Soft tissue sarcomas (STS) constitute an uncommon and heterogeneous group of tumors of mesenchymal origin and various cytogenetic abnormalities ranging from distinct genomic rearrangements, such as chromosomal translocations and amplifications, to more intricate rearrangements involving multiple chromosomes. Fluorescence in situ...

abstract liver neoplasm is not an uncommon disease in asian countries. liposarcoma is a rare mesenchymal malignant tumor which usually originates in the retroperitoneum and extremities. from 1973 till now about 10 cases of primary liver liposarcoma have been reported. we present the eleventh case in a young adult female with uncommon presentation. she suffered from a huge mass in the right port...

Background & Objective Soft tissue sarcomas (STS) constitute an uncommon and heterogeneous group of tumors of mesenchymal origin and various cytogenetic abnormalities ranging from distinct genomic rearrangements, such as chromosomal translocations and amplifications, to more intricate rearrangements involving multiple chromosomes. Fluorescence in situ hybridization (FISH) can be used to identif...