Limbic dysfunction and hypothalamo-pituitary-adrenocortical (HPA) axis dysregulation are key features of affective disorders. The following review summarizes our current understanding of the relationship between limbic structures and control of ACTH and glucocorticoid release, focusing on the hippocampus, medial prefrontal cortex and amygdala. In general, the hippocampus and anterior cingulate/...

This paper presents an overview of the limbic brain and its distributed sub-systems. The extent of the limbic system has expanded in recent years. Among the brain areas that we now argue should be included in the extended limbic system are the medial prefrontal cortex, the insular cortex as well as the lower brainstem and spinal cord. In addition the limbic forebrain and limbic midbrain may be ...

Tinnitus is a common disorder characterized by ringing in the ear in the absence of sound. Converging evidence suggests that tinnitus pathophysiology involves damage to peripheral and/or central auditory pathways. However, whether auditory system dysfunction is sufficient to explain chronic tinnitus is unclear, especially in light of evidence implicating other networks, including the limbic sys...

Background: Autoimmune limbic encephalitis is presented with the involvement of limbic structures. It is a diff erent entity rather than a component of paraneoplastic limbic encephalitis. In recent years, limbic encephalitis cases with immune-mediated voltage gated potassium channel antibody that respond to immunotherapies have been described. Case reports: We present two male patients aged 45 ...

Of six patients registered in our center with nonparaneoplastic limbic encephalitis associated with antibodies to voltage-gated potassium channels, the five men had rapid eye movement sleep behavior disorder (RBD) coincident with voltage-gated potassium channel antibody-associated limbic encephalitis onset. In three patients, immunosuppression resulted in resolution of RBD in parallel with remi...

The concept of the limbic system is highly influential in many areas of the neurosciences and in their applications to clinical medicine. The value of this concept has been questioned, denied, and defended several times in the past but a comprehensive critical evaluation has never been published. In this article we take several approaches to analyse empirical data of relevance to the limbic sys...

Anti-LGI1-associated autoimmune encephalitis is a limbic system pathology characterized by persistent seizures, cognitive and neuropsychiatric symptoms treated with immunomodulators depending on the etiology.