Well-defined heterofunctionalized glycosylated scaffolds with unprecedented molecular combinations have been prepared using up to five different bioorthogonal ligations. This approach opens up chemical access to a diversity of biomolecular structures with high biological potential.

We describe a cloning strategy, third irrelevant enzyme site (TIES), based on three-component assembly ligation reactions to overcome seven types of problematical cloning reactions. Implementation of the TIES strategy has made it possible to obtain the desired recombinant where the corresponding approach using conventional recombinant DNA methodologies and two-component ligations failed to give...

aim : the aim of this study was to assess the incidence of irritable bowel syndrome in women undergoing hysterectomy and tubular ligation. background : the results of previous studies have shown an increased incidence of irritable bowel syndrome after gynecological surgeries. patients and methods : participants were patients of alzahra and taleghani university hospitals in tabriz. one hundred a...

tubal ligation is one of the most effective and reliable methods of contraception and of successful program of birth control in iran. present study was done to evaluate factors affecting risk of complications during tubal ligation surgery. we studied 1780 women that had tubal ligation in 13 hospitals in tehran during the years 1993-95. data on operation were collected by questionnaire and analy...

introduction placenta accreta is an increasingly common complication of pregnancy that can result in massive hemorrhage. case presentation we describe two cases of placenta accreta, with successful conservative management in a referral hospital in tehran, iran. in both cases, two procedures were performed: compression suture (b-lynch) and a perfusion-decreasing procedure (bilateral uterine arte...

background: pancreatic anastomosis leakage and fistula formation following  pancreaticoduodenectomy (whipple’s procedure) is a common complication. delay in timely diagnosis and proper management is associated with high morbidity and mortality. to report our experience with management of pancreatic fistula following whipple’s procedure. materials and methods: in this retrospective study, medica...

we report a case of a woman presenting in a state of shock with classic symptoms of ruptured ectopic pregnancy. she had a history of tubal ligation done three years back. exploratory laparotomy was done, and a diagnosis of ruptured ectopic ovarian pregnancy was made.

Die Sortase-vermittelte Ligation (Engl. sortase-mediated ligation, SML) ist ein effektives Werkzeug der Proteinchemie, welches die von Peptiden mit LPxTG-Sortiermotiven und N-terminalen Glycin-Nukleophilen ermöglicht. Kopplung mehrerer Fragmente durch SML wird den erneuten Einbau eines Sortiermotivs in das Produkt verhindert. Hier beschreiben wir Multi-Fragment-SML auf Grundlage schaltbaren Sor...