During the last decades, palladium nanoparticles (Pd(0) NPs) and Pd(II) compounds were shown to be attractive catalysts for fine organic synthesis. Nanostructured Pd(0) or have a relatively low environmental impact, but, at same time, they are indispensable such processes as Suzuki cross-coupling. This paper describes preparation of supported/embedded in hyper-cross-linked polystyrene (HPS) com...

We describe the effects of the overexpression of noggin, a bone morphogenetic protein (BMP) inhibitor, on osteoblast differentiation and bone formation. Cells of the osteoblast and chondrocyte lineages, as well as bone marrow macrophages, showed intense beta-gal histo- or cytostaining in adult noggin+/- mice that had a LacZ transgene inserted at the site of noggin deletion. Despite identical BM...

BACKGROUND Small polyfunctionalized heterocyclic compounds play important roles in the drug discovery process and in the isolation and structural identification of biological macromolecules. It is expected that ready access to diverse sets of heterocycles can not only help improving the known biological and pharmacokinetic properties of drugs, but also assist the discovery of molecules that exh...

erbB2/Her2, a ligandless receptor kinase, has pleiotropic effects on mammalian development and human disease. The absence of erbB2 signaling in cardiac myocytes results in dilated cardiomyopathy in mice, resembling the cardiotoxic effects observed in a subset of breast cancer patients treated with the anti-Her2 antibody herceptin. Emerging evidence suggests that erbB2 is pivotal for integrating...

context: over the last few decades, extensive efforts have been made worldwide to develop nanomedicine delivery systems, especially via oral route for antidiabetic drugs. absorption of insulin is hindered by epithelial cells of gastrointestinal tract, acidic gastric ph and digestive enzymes. evidence acquisition: recent reports have identified and explained the beneficial role of several struct...

two different growth media, namely complex and defined media, were used to examine establishment of steady-state conditions in phosphate-limited culture system of saccharomyces cerevisiae cen.pk113-5d strain. using the defined growth medium, it was possible to obtain steady state condition in the continuous culture. the effect of phosphate concentration on the growth of s. cerevisiae in phospha...

an analytical model for a coastal boundary current was used to investigate heat and salt budget of exchange flows in the persian gulf as a marginal sea. coastal boundary currents exchange heat and freshwater with the mosphere and the offshore waters. as heat and salinity fluxes caused by air-sea interaction and eddy activities, different temperature and salinity associated with boundary current...

several transporters appear to be important in transporting various drugs. many patients, who receive morphine as analgesic medication, also receive other medications with potency of changing morphine transport by affecting p-glycoprotein (p-gp) and oatp2 transport system. this could influence morphine pharmacokinetics and pharmacodynamics. the aim of present study was to elucidate the transpor...

In this study, an investigation of long-term forecasts relating to the development of the transport sector in Poland is performed, including the ones by 2030 and 2050. Selected transport development forecasts from the perspective of the membership of Poland in the European Union are presented and most of all, from the perspective of national studies. The basement for the review was the prognosi...