The aim of this study was to compare the duration of analgesia produced by epidural injection of ketamine, lidocaine and xylazine in West African dwarf goats. Three healthy West African dwarf goats of varying ages were used for this study. After administration of each drug, the onset of action was recorded and the duration of action of each drug was determine through pin prick method at ten (10...

Cardiac arrhythmias are the principal cause of sudden death due to heart disease, and current therapy is inadequate. A novel approach for formulating a lidocaine-polyurethane controlled release matrix and implanting this drug delivery system directly onto the arrhythmic epicardium is reported. Lidocaine-HCl-polyurethane matrices (28% w/w) were fabricated and studied for their in vitro drug rele...

The effect of a local anesthetic, lidocaine hydrochloride (LC x HCl), on the bilayer systems of purified egg phosphatidylcholine (EPC), dipalmitoylphosphatidylcholine (DPPC) and dioleoylphosphatidylcholine (DOPC) was studied by means of small-angle X-ray scattering (SAXS), Prodan fluorescence and electrophoretic light scattering. In the liquid crystalline phase of EPC and DOPC bilayers, the con...

The objective of this project was to investigate the trends of changes in the crystal morphology of cocaine in the presence of the common adulterants, caffeine and lidocaine HCl. By performing gold chloride microcrystal tests on samples of cocaine with adulterants at 10, 20, and 50% concentrations, trends in the changes of the crystal morphology can be linked to specific adulterants and concent...

TRANSDERMAL AND TRANSBUCCAL DELIVERY OF LIDOCAINE AND NICOTINE: COMBINED EFFECTS OF IONTOPHORESIS AND CHEMICAL ENHANCERS by Ran Wei This study focused on the effects of iontophoresis and chemical enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate (NHT) through the skin and mucosa was evaluated for potential clinical applications. These two potential ...

A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were prepared using variable quantities of mucoadhesive agents, hydroxypropyl methyl cellulose (HPMC) and sodium alginate (SA). The formulations were evaluated for their physicochemical properties, mucoadhesive strength and mucoadhesion time, ...

Objective- Evaulation of analgesic and sedative characteristics of xylazine/ketaminecombination for caudal epidural analgesia in comparison with two routine agents in donkey.Design- Cross over study.Animals- Five healthy adult donkeys of both sexes with body weights ranging from 150-200 kg.Procedures- Three treatments [lidocaine HCl 2% (0.22 mg kg^-1), xylazine HCl 2% (0.17 mg kg^-1) and xylazi...

UNLABELLED The use of (99m)Tc-sulfur colloid lymphoscintigraphy for the determination of lymph flow patterns from a tumor site and localization of the sentinel node has been widely adopted. However, the effects of multiple injections of the radiopharmaceutical can range from mild discomfort to pain. pH-adjusted lidocaine HCl coadministered with (99m)Tc-sulfur colloid presents a risk of introduc...