Incubation of whole blood or PMNs in saline with 1O 2 or 1O molar concentrations of lidocaine causes a reversible inhibition of granulocyte adherence. A single bolus dose of lidocaine, 2.5 mg/kg, given intravenously inhibits adherence in rabbits by 55.4% at 5 mm, with return to normal by 1 5 mm after dose. When the bolus dose is followed by an infusion of lidocaine. 0.3 mg/kg/mm, adherence stay...

Lidocaine, as an anesthetic substance, is often used for surface and spinal anesthesia. However, studies have shown that lidocaine may induce transient neurological symptoms and cauda equina syndrome. In the present study the effects of the ginsenoside Rg1 (Rg1) on lidocaine‑induced apoptosis were assessed in Jurkat cells using flow cytometry and terminal deoxynucleotidyl transferase-mediated d...

This study assessed the effect of low (10 mg ⋅ kg-1 ⋅ h-1) and very high (18 mg ⋅ kg-1 ⋅ h-1) doses of lidocaine on defibrillation energy requirements (DER) to relate changes in indexes of sodium-channel blockade with changes in DER values using a dose-response study design. In group 1 (control; n = 6 pigs), DER values were determined at baseline and during treatment with 5% dextrose in water (...

AIM To compare the effectiveness of 2% prilocaine plain solution, 1% lidocaine hydrochloride, and 1% buffered lidocaine in local anesthesia and pain reduction during injection in laceration repair. METHODS A double-blind randomized prospective comparison study included 183 consecutive eligible adult patients with simple lacerations, admitted to the emergency department between January 2001 an...

BACKGROUND Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314 into nociceptors when coadministered with capsaicin, a transient receptor potential vanilloid 1 (TRPV1) channel agonist. However, the pain evoked by capsaicin before establishment of the QX-314-mediated block would limit clinical utility. Because TRPV1 channels are also ...

The purpose of this study was to evaluate the study the comparison effect of propranolol, caffeine and diazepam on lidocaine-induced convulsions in mice. The study was done in 4 groups (5 mice in each group). Lidocaine was administrated at dose 30 mg/kg intraperitoneally (IP) in group 1. Diazepam was injected at dose 2 mg/kg-IP 15 min before lidocaine in group 2. Propranolol was injected at dos...

We performed a prospective, randomized, and double-blind study comparing the top-up effects of 2% lidocaine/100 microg fentanyl/epinephrine (n=31) and 2% lidocaine/saline/epinephrine (n=30) when extending an epidural labor analgesia using low-dose ropivacaine and fentanyl. Survival analysis for the sensory blocks to the T4 level showed no statistically significant differences in onset time to T...

introduction lidocaine plus epinephrine is the most common anesthetic drug used in dentistry which has important cardiovascular side-effects like increase in blood pressure and cardiac arrhythmia. the goal of this study was to evaluat cardiovascular effects of one cartridge of 2% lidocaine + 1:80000 epinephrine. methods and materials 60 cases without any systemic diseases who had been admitted ...

OBJECTIVES To characterize the uptake, washout, and metabolism of lidocaine hydrochloride in the iris/ciliary body and cornea. METHODS Iris/ciliary body uptake of lidocaine hydrochloride was measured by incubating human and rabbit irides in radiolabeled carbon 14-1% lidocaine hydrochloride for 2 to 60 minutes. Washout was determined by incubating the iris in 14C-1% lidocaine hydrochloride for...

This study was performed to investigate the analgesic effect of lidocaine and a combination of lidocaine and ketamine following epidural administration in dromedary camels. Ten 12-18-month-old camels were randomly divided into two equal groups. In group L, the animals received 2% lidocaine (0.22 mg/kg) and in group LK the animals received a mixture of 10% ketamine (1 mg/kg) and 2% lidocaine (0....