Multinucleated keratinocytes (also known as multinucleated epidermal giant cells) are a frequently overlooked histological finding in noninfectious inflammatory dermatoses. They are sometimes found in conditions characterized by chronic rubbing and pruritus, such as lichen simplex chronicus or prurigo nodularis, and may be a helpful clue in making the clinical diagnosis. This finding must be di...

A 55-year-old male developed itching on the anterior aspects of both legs and the right ankle. Gradually over the next 5 years there was thickening of the skin on these areas followed by the appearance of hyperpigmented, scaly, severely itchy plaques. He also noticed the appearance of a thick, hard horn-like structure projecting from the surface of the right ankle lesion for the last 2 years. A...

Emotional tensions in predisposed subjects may play a key role in inducing a pruritic sensation, leading to a scratching that, becoming a self-perpetuating pathomechanism, may represent the main feature of two distinct cutaneous clinical entities: prurigo nodularis and lichen simplex chronicus. Psychogenic factors play a relevant role in both conditions, and they are often associated with depre...

A 47-year-old man with 3 years history of a pruritic plaque, 1×3 cm on his left leg attended a dermatology clinic. An incisional biopsy was done with the differential diagnoses of: 1) Hypertrophic lichen planus, 2) Lichen simplex chronicus, 3) Psoriasis, 4) Bowen's disease. A diagnosis of “Fibroepithelioma” was suggested by histopathologist who was not compatible with clinical diagnosis. Carefu...

BACKGROUND The pattern of eczema is altered by geography, habits of people and environmental factors and regional variation in skin structure and function. AIMS Our study was done to estimate frequency and patterns of lower leg and foot eczemas. METHODS A total of 200 patients with various types of lower leg and foot eczemas were recruited over a period of 2 years. Demographic and clinical ...

Background: The vulvar lichen simplex chronicus (VLSC) is a common condition in gynecologic clinics. Though VLSC not life-threatening, it usually causes pruritus, soreness and dispareunia, which cause general discomfort. exact etiology of unclear. This study was performed to explore the vaginal microbiota identify possible microbial factors attacks. Methods: Ninety women were recruited. 45 pati...

INTRODUCTION Dermatologic diseases of the vulva may cause dyspareunia. These disorders may be overlooked by gynecologists and urologists because of lack of residency training experience. Dermatologists who are most familiar with these diseases are infrequently trained in vulvovaginal examination. As such, these disorders are often improperly diagnosed and treated. AIM To describe the presenta...

A 64-year-old Asian man with a history of refractory atopic dermatitis (AD) presented with severe generalized pruritus. Results of examination revealed erythematous, lichenified, crusted plaques and papules, mainly on the chest, abdomen, back, and extremities. In addition, numerous firm, skin-colored papules were found on the anterior shins (Figure 1). The patient stated that he first noticed t...