نتایج جستجو برای: leydig

تعداد نتایج: 3705  

Journal: :Journal of Korean Medical Science 1996
E. J. Seo H. J. Kwon S. I. Shim

We Describe a case of ovarian serous cystadenoma having Sertoli-Leydig cell tumor, well differentiated, in the cystic septum. Well differentiated Sertoli-Leydig cell tumor coexisting with other tumor, including serous tumor, has not yet been described. In all cases of Sertoli-Leydig cell tumor with heterologous components or other tumors, the androblastomatous components are intermediately or p...

Journal: :Asian journal of andrology 2002
Da-Nian Qin Mary A Lung

AIM To further clarify the changes occurred in the testicular capsulotomized rats. METHODS In testicular capsulotomized and sham-operated rats, the cross sectional area, the nucleus diameter and the number of Leydig cells were morphologically analyzed by the Vidas Image Processing System connected to a microscope. RESULTS In the capsulotomized animals, the cross sectional area of Leydig cel...

Journal: :Annals of clinical and laboratory science 1979
I Damjanov S M Katz M A Jewett

Leydig cell tumors represent approximately one to three percent of all testicular tumors. Whereas in experimental animals predisposing conditions include administration of chemical carcinogens, hormones and heavy metals, environmental or endogenous factors in man are presently unrecognized. Leydig cell tumors do not show preferential lateralization or tendency for bilaterality. The symptoms are...

Journal: :Reproductive biology and endocrinology : RB&E 2004
Christof Geigerseder Richard FG Doepner Andrea Thalhammer Annette Krieger Artur Mayerhofer

The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABA(A) and GABA(B) receptors, it is possible that GABA may act as auto-/paracrine molecule to regulate Leydig cell function. The present study was aimed to examin...

2014
Richard Ivell Kee Heng Ravinder Anand-Ivell

The hypothalamic-pituitary-gonadal (HPG) axis comprises pulsatile GnRH from the hypothalamus impacting on the anterior pituitary to induce expression and release of both LH and FSH into the circulation. These in turn stimulate receptors on testicular Leydig and Sertoli cells, respectively, to promote steroidogenesis and spermatogenesis. Both Leydig and Sertoli cells exhibit negative feedback to...

Journal: :Development 2008
Hao Tang Jennifer Brennan Jeannie Karl Yoshio Hamada Lori Raetzman Blanche Capel

During testis development, fetal Leydig cells increase their population from a pool of progenitor cells rather than from proliferation of a differentiated cell population. However, the mechanism that regulates Leydig stem cell self-renewal and differentiation is unknown. Here, we show that blocking Notch signaling, by inhibiting gamma-secretase activity or deleting the downstream target gene Ha...

Journal: :The Journal of Cell Biology 2004
Michail S. Davidoff Ralf Middendorff Grigori Enikolopov Dieter Riethmacher Adolf F. Holstein Dieter Müller

The cells responsible for production of the male sex hormone testosterone, the Leydig cells of the testis, are post-mitotic cells with neuroendocrine characteristics. Their origin during ontogeny and regeneration processes is still a matter of debate. Here, we show that cells of testicular blood vessels, namely vascular smooth muscle cells and pericytes, are the progenitors of Leydig cells. Res...

2013
Iuliia Savchuk Olle Söder Konstantin Svechnikov

It is well known that estrogens and estrogen-like endocrine disruptors can suppress steroidogenic gene expression, attenuate androgen production and decrease differentiation of adult Leydig cell lineage. However, there is no information about the possible link between the potency of Leydig cells to produce androgens and their sensitivity to estrogenic stimuli. Thus, the present study explored t...

Journal: :Endocrinology 1999
M F Taylor M de Boer-Brouwer I Woolveridge K J Teerds I D Morris

Leydig cells undergo apoptosis in response to the cytotoxin ethane dimethanesulfonate (EDS), with numbers declining at 12-18 h and maximal apoptosis at 24 h postinjection. The Bcl-2 family members, Bcl-2, Bcl-xl, and Bax, appear not to be involved in this process. To further investigate this phenomena, a single dose of EDS was administered to adult rats to induce the killing of Leydig cells. Th...

2014
Meng-Shao Lai Yu-Sheng Cheng Pei-Rong Chen Shaw-Jenq Tsai Bu-Miin Huang

Fibroblast growth factor 9 (FGF9) is a multifunctional polypeptide belonging to the FGF family and has functions related to bone formation, lens-fiber differentiation, nerve development, gap-junction formation and sex determination. In a previous study, we demonstrated that FGF9 stimulates the production of testosterone in mouse Leydig cells. In the present study, we used both primary mouse Ley...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید