نتایج جستجو برای: leukotriene antagonists

تعداد نتایج: 55425  

2013
David M. Tobin Francisco J. Roca John P. Ray Dennis C. Ko Lalita Ramakrishnan

While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory state and tuberculosis susceptibility. Here we show that the LTB4-inactivating enzyme leukotriene B4 dehydrogenase/prostaglandin reductase 1 (LT...

Journal: :Journal of Gastroenterology and Hepatology 2021

Background and Aim: Aberrant crypt foci (ACF) in the rectum have been reported to correlate with risk of colorectal tumorigenesis are useful biomarkers for predicting cancer because they quantitative can be evaluated a short period time. Leukotriene receptor antagonists (LTRAs) inhibitory effects on various carcinomas, but their unknown. Based report that overexpresses cysteinyl leukotriene rec...

Journal: :Pediatrics and neonatology 2012
Chih-Hsing Hung

Asthma is a chronic inflammatory disease that affects >300 million people worldwide. However, inhaled corticosteroids (ICS), the gold standard therapy for persistent asthma, cannot suppress every component of airway inflammation and often fail to adequately penetrate the small airways in order completely suppress eosinophilia. Cysteinyl leukotrienes are important inflammatory factors that are i...

Journal: :Archives of disease in childhood 1995
E Mayatepek W D Lehmann

Endogenous cysteinyl leukotriene synthesis was assessed in 10 patients with Kawasaki disease and 10 healthy controls by measuring excretion of leukotriene E4 (LTE4) in urine. LTE4 was increased more than fivefold in patients with Kawasaki disease compared with controls (median (range) 55.3 (31.8-120.6) v 10.2 (7.1-14.9) nmol/mol creatinine); this suggests that cysteinyl leukotrienes are involve...

2005
James H. Shelhamer Sahrudaya Nagineni Sura Alsaaty Grzegorz Woszczek Rafal Pawliczak Hai-Yan Qi

Journal: :American journal of epidemiology 2014
Lingling Li William M Vollmer Melissa G Butler Pingsheng Wu Elyse O Kharbanda Ann Chen Wu

We compared the impact of 3 confounding adjustment procedures-covariate-adjusted regression, propensity score regression, and high-dimensional propensity score regression-to assess the effects of selected asthma controller medication use (leukotriene antagonists and inhaled corticosteroids) on the following 4 asthma-related adverse outcomes: emergency department visits, hospitalizations, oral c...

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