Background: Mutation in NPM1 gene has been reported to be the most common genetic mutation in de novo acute myeloid leukemia (AML). AML with NPM1 gene mutation usually presents with higher initial leukocyte and blast cell counts and negative CD34 expression. We aimed to investigate the difference of initial leukocyte counts, bone marrow blast cell counts and expression of CD34 among patients wi...

OBJECTIVE This study assessed the association of inflammatory markers, high-sensitivity C-reactive protein (hsCRP), and total leukocyte count with nonalcoholic fatty liver disease (NAFLD) in urban South Indians. SUBJECTS AND METHODS We randomly selected subjects with and without NAFLD (n=100 each) from the Chennai Urban Rural Epidemiology Study conducted in Chennai in south India. NAFLD was d...

The relationship of the peripheral leukocyte count to pulmonary function was examined in 1,510 men. There were 466 current cigarette smokers, 485 former cigarette smokers, and 559 never smokers enrolled in a longitudinal study of aging. Spirometry was performed twice on all subjects ten years apart. A multiple regression analysis indicated that leukocyte count was inversely related to baseline ...

By multivariate analysis of nine laboratory variables, a discriminant function value has been derived that differentiated between a group of 106 drug abusers and a group of 100 normal controls.The variables were serum phosphorus, glucose, lactate dehydrogenase, aspartate aminotransferase, and hematocrit, total leukocyte count, polymorphonuclear leukocyte count, lymphocyte count, and monocyte co...

OBJECTIVE The aim of the present study was to assess the association of leukocyte count and high sensitivity C-Reactive protein (hsCRP) with metabolic abnormalities in subjects with normal glucose tolerance. METHODS Subjects with Normal Glucose Tolerance (NGT) (n = 865) were recruited from the Chennai Urban Rural Epidemiology Study [CURES]. Standard methods were used for assessing hsCRP [Neph...

Whereas many differential leukocyte count methods for high somatic cell count (SCC) milk from mastitic cows are available, only a few have been developed for low SCC milk. We have developed a flow cytometric differential leukocyte count method for low SCC milk. The procedure consists of 1) 1.5 ml of diluted milk sample (30%, vol/vol dilution with PBS), 2) centrifugation, 3) leukocyte labeling w...

BACKGROUND AND PURPOSE Leukocyte count is an independent predictor of stroke. We investigated the association between leukocyte count and progression of aortic atheroma over 12 months in stroke/transient ischemic attack (TIA) patients. METHODS Consecutive ischemic stroke and transient ischemic attack patients underwent 12-month sequential transesophageal echocardiography and were assessed for...

BACKGROUND AND PURPOSE Leukocyte count has been associated with cardiovascular and cerebrovascular disease, including carotid plaque thickness, in several studies. We hypothesized that white blood cell count is associated with aortic arch plaque thickness (AAPT). METHODS Leukocyte count was measured in randomly selected stroke-free community participants undergoing transesophageal echocardiog...

BACKGROUND Low lung function is associated with increased morbidity and mortality. It is therefore of interest to identify biomarkers that are associated with impaired lung function. The aim of the study was to analyse associations of biomarkers and combinations of biomarkers with lung function in an elderly general population. METHODS Lung function (FEV1 and FVC) and a panel of 15 inflammato...