OBJECTIVE To assess the degree, cause, and consequence of delays from presenting signs to diagnosis of retinoblastoma. METHODS A retrospective chart review was conducted of 64 consecutive patients who presented to the Memorial Sloan-Kettering Cancer Center with newly diagnosed retinoblastoma. Seven patients with a positive family history were excluded. RESULTS The median times from presenti...

OBJECTIVES To identify the main symptoms of retinoblastoma and to determine the mean time between symptom onset and diagnosis (lag time). PATIENTS AND METHODS We carried out a retrospective analysis of the patients diagnosed with retinoblastoma between January 1991 and June 2000, at the Pediatric Department of the Hospital do Cancer, Sao Paulo, Brazil. Statistical analyses performed were: Stu...

Purpose To report the presenting signs of retinoblastoma in a large cohort patients who underwent orthoptic assessment at presentation. Methods A retrospective medical chart review was conducted on 131 with presented consecutively to single institution during 6-year period. The main outcome measure sign(s) disease. Results Of retinoblastoma, 88 unilateral disease and 43 bilateral (mean ages: 22...

A six-year-old boy, a known case of acute lymphoblastic leukaemia (ALL) on remission since 1991 presented with leukocoria and poor vision of the left eye for two days' duration. Examination revealed endophthalmitis in the left eye with raised intraocular pressure. Anterior chamber paracentesis with vitreous biopsy confirmed a diagnosis of ocular involvement. Further investigation revealed that ...

Leukocoria is a condition in which the normal red reflex of the retina is replaced by a yellowish or grayish white color. Retinoblastoma is the most common cause of leuko-coria in the pediatric age, followed by persistent fetal vasculature and Coats’ disease. Clinical and imaging signs and differential diagnosis features of these pathologies are evaluated.

Incontinentia pigmenti is a very rare X-linked dominant inherited disease characterized by skin lesions, retinal pathologies, central nervous system anomalies, and dental problems. Norrie recessive severe vitreoretinal dysplasia in both eyes at birth. In diseases, patients can apply to the clinic with nystagmus, leukocoria, microphthalmia, detachment an early age. this review, disease, which ar...