In 1933 Siwe laid down the criteria of the syndrome now called Letterer-Siwe disease, and in the literature before and after that date the different features are discussed and related to the reported cases. The following case illustrates in particular the peripheral blood changes which may occur in this condition, and a table is appended summarizing the clinical and pathological features of 18 ...

The fourteenth annual meeting of the Society for Pediatric Dennatology was held in Quebec City, Quebec, Canada and hosted by Drs. Beraice Krafchik, Lionel Boxall, and the dennatology staff of L'Hotel-Dieu de Quebec, particularly Drs. Raymond Lessard and Richard Cloutier. The fifth annual Sidney Hurwitz Lecture was presented by Professor Ruggero Caputo of the University of Milan. He discussed th...

In Letterer-Siwe disease, oral and dental pathology is an unusual occurrence. Failure to consider this condition in patients with gingival inflammation, necrosis, or premature eruption of teeth may lead to delay in diagnosis. We present two cases with these features. Case Reports Case 1. This boy was aged 4 months when he developed sore, swollen gums with white necrotic areas. He was treated fo...

Langerhans cell histiocytosis (LCH) and malignancy occurring in the same individual is unusual and has generally been the subject of isolated case reports. LCH is a rare condition in adults. Its cause is uncertain but, with the recent demonstration of clonality and its association with malignant disease, there has been a renewal of interest. We report a singular case of Letterer-Siwe disease as...

Eosinophilic granuloma was formerly mistaken for “eosinophilic myeloma” (Finzi 1929) or for “osteomyelitis with eosinophilic reaction” (Schairer 1938). It was described as a new distinct entity by Otani and Ehrlich (1940) under the denomination solitary granuloma of bone and by Jaffe and Lichtenstein (1944) as eosinophilic granuloma ofbone. Farber(l94l) and Green and Farber (1942) showed that e...