The early administration of tranexamic acid (TXA) to bleeding trauma patients reduces all-cause mortality without increasing the risk of vascular occlusive events. Indeed, the risk of arterial thrombosis appears to be reduced with TXA. In this commentary we hypothesize that TXA has an antithrombotic effect and explore potential mechanisms. These include inhibition of the inflammatory effects of...

Contrary to popular opinion, we find evidence that the views of residents of both higher and lower income neighborhoods are represented by their legislators. Analyzing the voting behavior of California state legislators on 77 proposals on which both the legislature and the public cast ballots, we find first that the opinions of higher and lower income voters within a district are highly correla...

Distal-less function Distal-less (Dll), as its name suggests, is required for distal limb development. Drosophila mutants lacking Dll function die as embryos because they lack the rudimentary larval limbs (Cohen and Jurgens, 1989). Viable combinations of Dll alleles of increasing severity can be used to generate a phenotypic series in which weak allelic combinations lead to fusions of the dista...