UNLABELLED Male infertility is one of the most stressful factors of couples, being present in about 40% cases. It is usually caused by a low number of sperm (oligozoospermia) or poor sperm motility (asthenozoospermia). The sperm motility is used as an indicator of semen quality and male infertility. To the impairment of male reproduction health can contribute genetic, nutritional and environmen...

BACKGROUND To determine any correlation between infertility and semen quality with concentrations of L-carnitine in human seminal plasma. METHODS This case-control study performed in Fatemieh Hospital in Hamadan, Iran. Seminal plasma of 72 infertile men and 80 men with proved fertility as a control group was investigated and L-carnitine level was determined using UV enzymatic test at 340 nm. ...

Male infertility can be treated by surgical procedures (e.g., varicocelectomy) or by administration of drugs if causal factors (e.g., seminal tract infections) are detected. In more severe cases, methods of assisted fertilization often have to be applied, but even these have only a limited success rate. Recent studies have demonstrated that disturbances of sperm DNA integrity (determined by the...

Infertility is an important aspect of human reproduction. It affects up to 15% of couples, with the male factor contributing to approximately 50% of all cases. Azoospermia is one of the most severe forms of male infertility, which is characterized by the absence of sperm in semen. The mechanisms underlying male infertility remain unknown. Currently, clinicians rely on semen analysis to predict ...

Seminal plasma is complex fluid containing a wide variety of both organic and inorganic components, among which proteins are an important part of the high-molecular-weight substances. The protein composition of mammalian seminal plasma varies in species and has important effect on sperm functions such as sperm motility (Henricks et al., 1998), viability (Brandon et al., 1999) and freezability (...

Introduction: Leptin is a critical metabolic signal linking nutrition and reproductive functions. Leptin receptors are expressed in germ cells, Sertoli and Leydig cells. Oxidative stress increases sperm DNA damages. Nitric oxide is a free radical, produced by most cells via Nitric Oxide (NO) synthase and plays stimulatory and inhibitory roles on cells. Physiological concentrations of NO are ess...

The nature of subfertility due to the male or inseminate is as complex as that of the female. Fertilization failure or failure in embryogenesis are both documented to be of seminal origin. Males also differ in the numbers of sperm required to reach their maximum fertilization rate. Males requiring more sperm would be considered to have compensable seminal deficiencies. These include a number of...

Background: Oxidative stress and decreased antioxidant levels have been projected as a potential factors involved in the pathophysiology of diverse male infertility types, including asthenospermia. The generation of reactive oxygen species (ROS) in the male reproductive tract has become an actual concern because of their probable noxious effects, at high levels, on physical properties of sperm ...

The rate of obesity among men of reproductive age has tripled in the last three decades. Previously, we demonstrated that paternal obesity resulted in impaired preimplantation developmental kinetics, compromised post-compaction metabolism and decreased blastocyst cell number when embryos were generated in vivo. Subsequently, using in vitro fertilization we found embryos of obese males to have a...