Uterine leiomyoma is the most common uterine neoplasm of women. The latest statistics confirm that uterine leiomyomas are present in 20-50% women of reproductive age [1]. Indeed, they are found in up to 77% of women if the uterus is examined closely at autopsy [2]. The incidence of uterine leiomyomas in pregnancy varies from 1.6% to 10.7% according to the trimester of assessment and the size th...

Background: Leiomyomas represent the most common benign uterine tumors. Typically asymptomatic, they may determine menometrorrhagia, abdominal pain and infertility. They may be singular or multiple and may have variable size. When leiomyomas increase in size, their vascular supply may become insufficient determining different types of degeneration: hyaline, myxoid, cystic and hemorrhagic (red)....

To investigate the association between widespread use of mifepristone in abortions and risk of uterine leiomyomas.We conducted a case-control study of 305 patients with uterine leiomyomas between January 2011 and July 2012; 311 women with ordinary vaginitis were selected as controls during the same period. Data were collected by questionnaires (including past history, life history, menstruation...

We recently found that aberrant DNA hypomethylation is more common on the X chromosome than on other chromosomes in uterine leiomyomas by genome-wide DNA methylation profiling. To investigate the mechanism of aberrant hypomethylation on the X chromosome in uterine leiomyomas, we analyzed methylome and transcriptome data from three cases of leiomyomas and the adjacent myometrium. We found that e...

Uterine leiomyomas, or fibroids, are extremely common tumors. Regardless of their benign nature, fibroids can cause considerable morbidity. Women with African ancestry have a threefold increased risk of developing uterine leiomyomas with a greater symptom severity when compared to white women. Recently, we demonstrated that exon 2 of the MED12 gene is somatically altered in up to 70 per cent of...

background:   uterine myomas are common pelvic masses during pregnancy. the pain and rapid growth of myomas are among the most common complications during pregnancy. we evaluate management of painful cystic degeneration of myomas during pregnancy case: a 27-year-old primigravida had a pelvic mass. we have managed a case in which the diagnosis of cystic degeneration of uterine myomas could not b...

Leiomyomas are benign tumors of smooth muscle origin occurring throughout the genitourinary system. While leiomyomas in the uterus are frequently seen, urethral and paraurethral leiomyomas are extremely rare with a hand full of cases in the literature. Typically, periurethral leiomyomas can present with a mass protruding from the urethra originating from the proximal and posterior portion of th...

Pregnant women with uterine leiomyomas may experience anxiety toward their pregnancies and unfavorable feelings toward their infants. From March to July 2010, we distributed anonymous self-recorded questionnaires to 200 pregnant women who visited Okayama Central Hospital for an antenatal check-up after informed consent was provided, and 132 women (23 pregnant women with uterine leiomyomas) were...

GnRH agonist (GnRH-a) therapy is known to shrink uterine leiomyoma, although the molecular mechanisms responsible for this effect remain poorly understood. Conflicting results exist as to whether GnRH-a treatment increases apoptosis in leiomyoma cells. The aim of this study is to investigate the effects of GnRH-a on uterine leiomyomas by profiling the expression levels of apoptosis-related mole...