Athletes commonly develop what is regarded as a benign increase in cardiac mass in response to physical training. However, prolonged training may lead to a degree of cardiac remodeling that mimics hypertrophic cardiomyopathy (HCM). Left ventricular hypertrophy (LVH) can be defined echocardiographically as a left ventricular wall thickness (LVWT) of greater than 12mm. A LVWT of 12-16mm represent...

Background Left ventricular hypertrophy (LVH) with Left ventricular maximal thickness (LVMT) ≥15 mm as a current criteria to differentiate hypertrophic cardiomyopathy (HCM) from other causes of LVH lacks specificity. The recent findings of intrinsic mitral valve leaflet elongation in HCM may potentially distinguish HCM from other causes of LVH. We aim to studying the performance of mitral valve...

Perfusion abnormalities in the pressure-overloaded hypertrophied left ventricle could result from an increase in minimum coronary resistance or an increase in effective back pressure due to increased extravascular compressive forces. Since the pressure-flow relation of the maximally vasodilated coronary bed allows dissociation of minimum resistance (inverse slope [1/acPFI) and back pressure (pr...

Perfusion abnormalities in the pressure-overloaded hypertrophied left ventricle could result from an increase in minimum coronary resistance or an increase in effective back pressure due to increased extravascular compressive forces. Since the pressure-flow relation of the maximally vasodilated coronary bed allows dissociation of minimum resistance (inverse slope [1/acPFI) and back pressure (pr...

BACKGROUND Left ventricular hypertrophy (LVH) induced by exercise is considered to be a physiologic adaptive mechanism without fibrogenic hyperactivity, as occurs in pathologic hypertrophy. HYPOTHESIS This study investigated serum markers of collagen synthesis and echo parameters of left ventricular diastolic function (LVdf) in 22 male athletes. METHODS Twenty-two highly competitive male at...

Objective To investigate the prevalence of left ventricular hypertrophy (LVH) and different patterns of left ventricular (LV) geometry and their risk factors in untreated hypertension population in China. Methods A total of 9,286 participants (5167 males and 4119 females) were recruited from two Chinese communities. The LV geometry was classified into four patterns: normal; abnormal,defined as ...

Abbreviations: BSA – basic surface area, H-LVH – hypertension with left ventricular hypertrophy, H­NLVH – hypertension with­ out left ventricular hypertrophy, IVST – interventricular septum thickness in diastole, LEPR – leptin receptor, LVDd – left ven­ tricular end­diastolic diameter, LVH – left ventricular hypertro­ phy, LVM – left ventricular mass, LVMI – left ventricular mass index, PVST – ...

Background and objectives: Resveratrol(3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenole phytoalexin which exerts potential cardioprotective effects, but the cellular and molecular mechanisms responsible for these effects are still unknown. Cardiac renin angiotensin system (RAS) over-activation plays an important role in pathogenesis of left ventricula...

Frequently an underwriter or medical director will question whether an increase in left ventricular mass represents pathologic left ventricular hypertrophy (LVH) or physiologic changes related to exercise. The LVH condition reflects end-organ damage related to abnormal hemodynamic stresses and confers an increased morbidity and mortality risk. When left ventricular mass is increased because of ...

BACKGROUND Hypertrophic cardiomyopathy (HCM) is an inherited disease of the sarcomere characterised clinically by myocardial hypertrophy and its consequences. Phenotypic expression is heterogeneous even within families with the same aetiological mutation and may be influenced by additional genetic factors. OBJECTIVE To determine the influence of genetic polymorphisms of the renin-angiotensin-...